| Date | H/A | W/L | Team | Score | Opponent | Score | |||
| 2021-03-05 | A | L | St. Joseph | 48 | Raceland (KY) | 55 | 1043 | ||
| 2021-03-06 | H | W | St. Joseph | 58 | Wahama | 56 | 901 | ||
| 2021-03-09 | A | L | St. Joseph | 70 | Beth Haven (WV) | 86 | 1042 | ||
| 2021-03-12 | A | L | St. Joseph | 52 | Grace Christian Acad (WV) | 79 | 1041 | ||
| 2021-03-13 | H | W | St. Joseph | 72 | Carter Christian (KY) | 51 | 1040 | ||
| 2021-03-15 | H | L | St. Joseph | 41 | Ravenswood | 65 | 752 | ||
| 2021-03-18 | H | L | St. Joseph | 49 | Tolsia | 60 | 1039 | ||
| 2021-03-23 | A | L | St. Joseph | 54 | Carter Christian (KY) | 71 | 1038 | ||
| 2021-03-25 | A | L | St. Joseph | 59 | Wayne | 67 | 547 | ||
| 2021-03-27 | A | L | St. Joseph | 53 | Tolsia | 70 | 1055 | ||
| 2021-04-08 | H | L | St. Joseph | 50 | Wayne | 60 | 553 | ||
| 2021-04-13 | A | L | St. Joseph | 47 | Wahama | 67 | 897 | ||
| 2021-04-21 | A | L | St. Joseph | 49 | Buffalo | 76 | 1191 |