| Date | Score | Score | ||||
| 2025-03-03 | Pocahontas County | 48 | Webster County ** | 52 | ||
| 2025-03-03 | James Monroe | 65 | PikeView ** | 62 | ||
| 2025-03-03 | South Harrison | 52 | Liberty-Harrison ** | 60 | ||
| 2025-03-03 | Chapmanville Regional | 80 | Greater Beckley Christian ** | 76 | ||
| 2025-03-03 | East Fairmont | 41 | Buckhannon-Upshur ** | 48 | ||
| 2025-03-03 | Grafton | 42 | North Marion ** | 81 | ||
| 2025-03-03 | Wayne | 63 | Buffalo ** | 38 | ||
| 2025-03-03 | Hurricane | 55 | Cabell Midland ** | 76 | ||
| 2025-03-03 | Mt. Hope Christian (WV) | 50 | Midland Trail ** | 73 | ||
| 2025-03-04 | Pocahontas County | 30 | Union ** | 43 | ||
| 2025-03-04 | Tygarts Valley | 78 | South Harrison ** | 83 | ||
| 2025-03-04 | Bluefield | 53 | Woodrow Wilson ** | 83 | ||
| 2025-03-04 | Logan | 64 | Tug Valley ** | 83 | ||
| 2025-03-04 | Ravenswood | 49 | Roane County ** | 38 | ||
| 2025-03-04 | Williamstown | 68 | Tyler Consolidated ** | 44 | ||
| 2025-03-04 | Elkins | 52 | Preston ** | 37 | ||
| 2025-03-04 | Fairmont Sr. | 38 | Bridgeport ** | 56 | ||
| 2025-03-04 | Frankfort | 51 | East Hardy ** | 68 | ||
| 2025-03-04 | Independence | 55 | Liberty-Raleigh ** | 45 | ||
| 2025-03-04 | Nitro | 61 | Winfield ** | 49 | ||
| 2025-03-04 | Parkersburg South | 53 | South Charleston ** | 77 | ||
| 2025-03-05 | Calhoun County | 32 | Gilmer County ** | 71 | ||
| 2025-03-05 | Hannan | 64 | Tolsia ** | 107 | ||
| 2025-03-05 | Hundred | 66 | Cameron ** | 76 | 1 OT | |
| 2025-03-05 | Madonna | 85 | Trinity ** | 73 | ||
| 2025-03-05 | Paden City | 24 | Wood Co. Christian ** | 73 | ||
| 2025-03-05 | Van | 40 | Man ** | 73 | ||
| 2025-03-05 | Nicholas County | 44 | Sissonville ** | 57 | ||
| 2025-03-06 | George Washington | 35 | Morgantown ** | 57 | ||
| 2025-03-07 | Cameron | 44 | Magnolia ** | 79 | ||
| 2025-03-07 | Gilmer County | 49 | Tug Valley ** | 86 | ||
| 2025-03-07 | Greenbrier West | 54 | Mt. View ** | 66 | ||
| 2025-03-07 | Madonna | 58 | Clay-Battelle ** | 66 | ||
| 2025-03-07 | Man | 47 | Wahama ** | 58 | ||
| 2025-03-07 | Meadow Bridge | 31 | Greater Beckley Christian ** | 97 | ||
| 2025-03-07 | Parkersburg Catholic | 60 | Notre Dame ** | 40 | ||
| 2025-03-07 | Paw Paw | 60 | Tygarts Valley ** | 79 | ||
| 2025-03-07 | Pocahontas County | 33 | East Hardy ** | 92 | ||
| 2025-03-07 | Richwood | 25 | Montcalm ** | 63 | ||
| 2025-03-07 | River View | 52 | Webster County ** | 56 | ||
| 2025-03-07 | Tolsia | 59 | St. Joseph ** | 67 | ||
| 2025-03-07 | Union | 45 | Pendleton County ** | 61 | ||
| 2025-03-07 | Wirt County | 42 | Sherman ** | 48 | ||
| 2025-03-07 | Wood Co. Christian | 48 | Valley-Wetzel ** | 54 | ||
| 2025-03-07 | Bluefield | 79 | James Monroe ** | 67 | ||
| 2025-03-07 | Clay County | 60 | Scott ** | 99 | ||
| 2025-03-07 | Liberty-Raleigh | 47 | Midland Trail ** | 49 | 1 OT | |
| 2025-03-07 | Mingo Central | 55 | Westside ** | 80 | ||
| 2025-03-07 | Moorefield | 39 | Doddridge County ** | 74 | ||
| 2025-03-07 | Oak Glen | 54 | Tyler Consolidated ** | 66 | ||
| 2025-03-07 | Petersburg | 50 | Liberty-Harrison ** | 55 | ||
| 2025-03-07 | Philip Barbour | 55 | Braxton County ** | 50 | ||
| 2025-03-07 | Poca | 32 | Charleston Catholic ** | 58 | ||
| 2025-03-07 | Roane County | 45 | Buffalo ** | 52 | ||
| 2025-03-07 | South Harrison | 46 | Ritchie County ** | 55 | ||
| 2025-03-07 | St. Marys | 41 | Ravenswood ** | 83 | ||
| 2025-03-07 | Summers County | 57 | Wyoming East ** | 78 | ||
| 2025-03-07 | Berkeley Springs | 30 | Bridgeport ** | 77 | ||
| 2025-03-07 | Brooke | 52 | East Fairmont ** | 49 | ||
| 2025-03-07 | Frankfort | 56 | Lewis County ** | 66 | ||
| 2025-03-07 | Grafton | 23 | Elkins ** | 57 | ||
| 2025-03-07 | Independence | 50 | Greenbrier East ** | 55 | ||
| 2025-03-07 | Keyser | 51 | Hampshire ** | 55 | ||
| 2025-03-07 | Lincoln | 41 | Robert C. Byrd ** | 52 | ||
| 2025-03-07 | Lincoln County | 58 | Wayne ** | 74 | ||
| 2025-03-07 | PikeView | 75 | Ripley ** | 88 | ||
| 2025-03-07 | Princeton | 49 | Herbert Hoover ** | 63 | ||
| 2025-03-07 | Pt. Pleasant | 37 | Winfield ** | 63 | ||
| 2025-03-07 | Sissonville | 58 | Shady Spring ** | 75 | ||
| 2025-03-07 | Weir | 50 | North Marion ** | 55 | ||
| 2025-03-07 | Capital | 64 | Parkersburg South ** | 71 | ||
| 2025-03-07 | Hurricane | 58 | Huntington ** | 60 | ||
| 2025-03-07 | Jefferson | 45 | Hedgesville ** | 28 | ||
| 2025-03-07 | John Marshall | 45 | Buckhannon-Upshur ** | 49 | ||
| 2025-03-07 | Musselman | 58 | Washington ** | 62 | ||
| 2025-03-07 | Oak Hill | 40 | St. Albans ** | 68 | ||
| 2025-03-07 | Parkersburg | 68 | Cabell Midland ** | 60 | ||
| 2025-03-07 | Riverside | 59 | Woodrow Wilson ** | 88 | ||
| 2025-03-07 | Wheeling Park | 49 | Preston ** | 52 |