| Date | Score | Score | ||||
| 2025-03-11 | Buckhannon-Upshur | 54 | University ** | 65 | ||
| 2025-03-11 | Huntington | 54 | Parkersburg South ** | 63 | ||
| 2025-03-11 | Jefferson | 52 | Spring Mills ** | 79 | ||
| 2025-03-11 | Parkersburg | 53 | Spring Valley ** | 70 | ||
| 2025-03-11 | Preston | 38 | Morgantown ** | 81 | ||
| 2025-03-11 | St. Albans | 38 | George Washington ** | 48 | ||
| 2025-03-11 | Washington | 43 | Martinsburg ** | 58 | ||
| 2025-03-11 | Woodrow Wilson | 56 | South Charleston ** | 43 | ||
| 2025-03-12 | Mt. View | 46 | Greater Beckley Christian ** | 72 | ||
| 2025-03-12 | Parkersburg Catholic | 65 | Clay-Battelle ** | 75 | ||
| 2025-03-12 | Pendleton County | 37 | Tucker County ** | 82 | ||
| 2025-03-12 | Sherman | 34 | Tug Valley ** | 73 | ||
| 2025-03-12 | Tygarts Valley | 34 | East Hardy ** | 53 | ||
| 2025-03-12 | Valley-Wetzel | 56 | Magnolia ** | 78 | ||
| 2025-03-12 | Wahama | 50 | St. Joseph ** | 62 | ||
| 2025-03-12 | Webster County | 53 | Montcalm ** | 62 | ||
| 2025-03-12 | Bluefield | 40 | Wyoming East ** | 52 | ||
| 2025-03-12 | Buffalo | 44 | Scott ** | 41 | ||
| 2025-03-12 | Charleston Catholic | 39 | Logan ** | 54 | ||
| 2025-03-12 | Liberty-Harrison | 36 | Doddridge County ** | 54 | ||
| 2025-03-12 | Midland Trail | 48 | Westside ** | 66 | ||
| 2025-03-12 | Philip Barbour | 40 | Ritchie County ** | 48 | 1 OT | |
| 2025-03-12 | Ravenswood | 46 | Wheeling Central ** | 64 | ||
| 2025-03-12 | Tyler Consolidated | 37 | Williamstown ** | 70 | ||
| 2025-03-13 | Brooke | 46 | Fairmont Sr. ** | 79 | ||
| 2025-03-13 | Greenbrier East | 40 | Ripley ** | 57 | ||
| 2025-03-13 | Hampshire | 23 | Bridgeport ** | 56 | ||
| 2025-03-13 | Herbert Hoover | 46 | Shady Spring ** | 66 | ||
| 2025-03-13 | Lewis County | 55 | Robert C. Byrd ** | 60 | ||
| 2025-03-13 | North Marion | 33 | Elkins ** | 46 | ||
| 2025-03-13 | Wayne | 44 | Chapmanville Regional ** | 63 | ||
| 2025-03-13 | Winfield | 43 | Nitro ** | 49 |