| Date | Score | Score | ||||
| 2025-03-18 | Buffalo | 39 | Williamstown ** | 74 | ||
| 2025-03-18 | Doddridge County | 53 | Westside ** | 83 | ||
| 2025-03-18 | Logan | 42 | Wyoming East ** | 44 | ||
| 2025-03-18 | Ritchie County | 27 | Wheeling Central ** | 80 | ||
| 2025-03-18 | Chapmanville Regional | 46 | Fairmont Sr. ** | 47 | ||
| 2025-03-18 | Elkins | 32 | Bridgeport ** | 55 | ||
| 2025-03-19 | Ripley | 45 | Nitro ** | 48 | ||
| 2025-03-19 | Robert C. Byrd | 43 | Shady Spring ** | 60 | ||
| 2025-03-19 | Martinsburg | 43 | Spring Mills ** | 65 | ||
| 2025-03-19 | Parkersburg South | 50 | Morgantown ** | 59 | ||
| 2025-03-19 | University | 42 | George Washington ** | 62 | ||
| 2025-03-19 | Woodrow Wilson | 44 | Spring Valley ** | 61 | ||
| 2025-03-20 | Clay-Battelle | 34 | East Hardy ** | 51 | ||
| 2025-03-20 | Magnolia | 47 | Tucker County ** | 59 | ||
| 2025-03-20 | Montcalm | 36 | Tug Valley ** | 67 | ||
| 2025-03-20 | St. Joseph | 52 | Greater Beckley Christian ** | 60 | ||
| 2025-03-20 | Westside | 38 | Wheeling Central ** | 57 | ||
| 2025-03-20 | Wyoming East | 51 | Williamstown ** | 61 | ||
| 2025-03-21 | East Hardy | 36 | Tucker County ** | 42 | ||
| 2025-03-21 | Greater Beckley Christian | 63 | Tug Valley ** | 71 | ||
| 2025-03-21 | Fairmont Sr. | 30 | Bridgeport ** | 46 | ||
| 2025-03-21 | Nitro | 63 | Shady Spring ** | 49 | ||
| 2025-03-21 | George Washington | 49 | Morgantown ** | 47 | ||
| 2025-03-21 | Spring Valley | 51 | Spring Mills ** | 92 | ||
| 2025-03-22 | Tucker County | 45 | Tug Valley ** | 65 | ||
| 2025-03-22 | Wheeling Central | 59 | Williamstown ** | 40 | ||
| 2025-03-22 | Nitro | 40 | Bridgeport ** | 62 | ||
| 2025-03-22 | George Washington | 38 | Spring Mills ** | 41 |