| Date |
|
Score |
|
Score |
|
|
| 2008-09-18 | Wyoming East ** | 24 | Summers County | 0 | | |
| 2008-09-18 | Fairmont Sr. ** | 35 | Preston | 28 | | |
| 2008-09-18 | Brashear (PA) | 41 | Allderdice (PA) ** | 6 | | |
| 2008-09-19 | Big Creek ** | 38 | Hurley (VA) | 6 | | |
| 2008-09-19 | Clay-Battelle ** | 49 | Hundred | 0 | | |
| 2008-09-19 | Fayetteville ** | 59 | Meadow Bridge | 8 | | |
| 2008-09-19 | Gilbert ** | 42 | Williamson | 14 | | |
| 2008-09-19 | Gilmer County | 32 | Notre Dame ** | 28 | | |
| 2008-09-19 | Iaeger | 21 | Van ** | 12 | | |
| 2008-09-19 | Madonna ** | 53 | Valley-Wetzel | 6 | | |
| 2008-09-19 | Matewan | 37 | Buffalo ** | 12 | | |
| 2008-09-19 | Midland Trail ** | 39 | Richwood | 6 | | |
| 2008-09-19 | Montcalm ** | 54 | Burch | 12 | | |
| 2008-09-19 | Moorefield | 27 | Tucker County ** | 12 | | |
| 2008-09-19 | Mt. Hope ** | 52 | Pendleton County | 20 | | |
| 2008-09-19 | Pocahontas County ** | 68 | East Hardy | 20 | | |
| 2008-09-19 | St. Marys ** | 38 | Man | 12 | | |
| 2008-09-19 | Wahama | 28 | Buckeye Trail (OH) ** | 27 | | |
| 2008-09-19 | Wheeling Central ** | 43 | Morgan (OH) | 13 | | |
| 2008-09-19 | Williamstown ** | 41 | South Harrison | 8 | | |
| 2008-09-19 | Wirt County ** | 41 | Doddridge County | 0 | | |
| 2008-09-19 | Braxton County | 22 | Ritchie County ** | 15 | | |
| 2008-09-19 | Chapmanville ** | 28 | Poca | 12 | | |
| 2008-09-19 | Frankfort | 36 | Berkeley Springs ** | 14 | | |
| 2008-09-19 | Grafton | 53 | Tyler Consolidated ** | 21 | | |
| 2008-09-19 | Greenbrier West | 62 | Oak Hill ** | 22 | | |
| 2008-09-19 | Herbert Hoover ** | 21 | Logan | 7 | | |
| 2008-09-19 | James Monroe ** | 17 | PikeView | 6 | | |
| 2008-09-19 | Keyser | 33 | Northern Garrett County (MD) ** | 6 | | |
| 2008-09-19 | Liberty-Raleigh | 40 | Mt. View ** | 26 | | |
| 2008-09-19 | Oak Glen ** | 53 | Toronto (OH) | 29 | | |
| 2008-09-19 | Philip Barbour ** | 29 | Langley (PA) | 26 | | |
| 2008-09-19 | Pt. Pleasant | 41 | Tug Valley ** | 6 | | |
| 2008-09-19 | Scott | 50 | Westside ** | 20 | | |
| 2008-09-19 | Shady Spring ** | 21 | Independence | 12 | | |
| 2008-09-19 | Sissonville | 20 | Clay County ** | 13 | | |
| 2008-09-19 | Wayne | 39 | Winfield ** | 27 | | |
| 2008-09-19 | Webster County ** | 28 | Roane County | 21 | | |
| 2008-09-19 | Bridgeport ** | 46 | Calvin Coolidge (DC) | 25 | | |
| 2008-09-19 | Buckhannon-Upshur ** | 39 | North Marion | 26 | | |
| 2008-09-19 | Cabell Midland | 36 | Lincoln County ** | 29 | | |
| 2008-09-19 | Capital | 17 | Ripley ** | 7 | | |
| 2008-09-19 | George Washington ** | 42 | Greenbrier East | 0 | | |
| 2008-09-19 | Hurricane | 42 | Huntington ** | 28 | | |
| 2008-09-19 | Lewis County ** | 56 | Lincoln | 14 | | |
| 2008-09-19 | Martinsburg | 55 | Washington ** | 8 | | |
| 2008-09-19 | Morgantown | 44 | East Fairmont ** | 3 | | |
| 2008-09-19 | Musselman | 25 | North Hagerstown (MD) ** | 0 | | |
| 2008-09-19 | Nicholas County ** | 38 | Sherman | 7 | | |
| 2008-09-19 | Parkersburg ** | 35 | Riverside | 34 | | |
| 2008-09-19 | Robert C. Byrd ** | 56 | Liberty-Harrison | 7 | | |
| 2008-09-19 | South Charleston | 28 | St. Albans ** | 14 | | |
| 2008-09-19 | Spring Valley ** | 47 | Nitro | 12 | | |
| 2008-09-19 | University ** | 42 | Elkins | 12 | | |
| 2008-09-19 | Wheeling Park | 31 | Brooke ** | 13 | | |
| 2008-09-19 | Woodrow Wilson ** | 30 | Princeton | 13 | | |
| 2008-09-19 | McKinley (DC) | 24 | Wilson (DC) ** | 14 | | |
| 2008-09-19 | Belfry (KY) ** | 47 | Shelby Valley (KY) | 6 | | |
| 2008-09-19 | Berea (KY) ** | 53 | Beth Haven (KY) | 12 | | |
| 2008-09-19 | Betsy Layne (KY) | 52 | South Floyd (KY) ** | 42 | | |
| 2008-09-19 | Boyd County (KY) ** | 39 | Pike Central (KY) | 15 | | |
| 2008-09-19 | Allegany (MD) | 34 | Mt. Ridge (MD) ** | 14 | | |
| 2008-09-19 | Boonsboro (MD) ** | 55 | Poolesville (MD) | 0 | | |
| 2008-09-19 | DeMatha (MD) | 22 | Friendship Collegiate (DC) ** | 8 | | |
| 2008-09-19 | Fort Hill (MD) ** | 2 | Dunbar (DC) | 0 | | |
| 2008-09-19 | Linganore (MD) | 40 | South Hagerstown (MD) ** | 0 | | |
| 2008-09-19 | Southern Garrett County (MD) ** | 14 | Hampshire | 12 | | |
| 2008-09-19 | Urbana (MD) ** | 41 | Jefferson | 6 | | |
| 2008-09-19 | Charlotte Country Day Sch (NC) ** | 35 | Bluefield | 14 | | |
| 2008-09-19 | Athens (OH) ** | 25 | Vinton County (OH) | 7 | | |
| 2008-09-19 | Beallsville (OH) | 50 | Frontier (OH) ** | 20 | | |
| 2008-09-19 | Bellaire St.John (OH) | 27 | Bishop Donahue ** | 26 | | |
| 2008-09-19 | Bridgeport (OH) ** | 40 | Paden City | 16 | | |
| 2008-09-19 | Buckeye Local (OH) ** | 46 | Indian Creek (OH) | 15 | | |
| 2008-09-19 | Claymont (OH) ** | 32 | Meadowbrook (OH) | 13 | | |
| 2008-09-19 | Columbiana Crestview (OH) | 34 | East Palestine (OH) ** | 28 | | |
| 2008-09-19 | Gallia Academy (OH) ** | 36 | Jackson (OH) | 28 | | |
| 2008-09-19 | Harrison Central (OH) | 43 | Edison Local (OH) ** | 13 | | |
| 2008-09-19 | John Adams (OH) ** | 34 | Rhodes (OH) | 6 | | |
| 2008-09-19 | Maple Heights (OH) | 34 | East Liverpool (OH) ** | 3 | | |
| 2008-09-19 | Marietta (OH) ** | 42 | Parkersburg South | 28 | | |
| 2008-09-19 | Monroe Central (OH) | 45 | Fort Frye (OH) ** | 7 | | |
| 2008-09-19 | Portsmouth Notre Dame (OH) | 35 | South Gallia (OH) ** | 6 | | |
| 2008-09-19 | Portsmouth West (OH) | 49 | Chesapeake (OH) ** | 20 | | |
| 2008-09-19 | Racine Southern (OH) ** | 31 | Green (OH) | 14 | | |
| 2008-09-19 | River (OH) | 14 | Caldwell (OH) ** | 7 | | |
| 2008-09-19 | Sciotoville Community (OH) | 72 | Manchester (OH) ** | 38 | | |
| 2008-09-19 | Shenandoah (OH) ** | 27 | Barnesville (OH) | 6 | | |
| 2008-09-19 | South Point (OH) ** | 28 | Valley (OH) | 7 | | |
| 2008-09-19 | St. Clairsville (OH) ** | 35 | Weir | 17 | | |
| 2008-09-19 | Steubenville (OH) | 42 | Beaver Local (OH) ** | 7 | | |
| 2008-09-19 | Symmes Valley (OH) | 28 | Northwest McDermott (OH) ** | 6 | | |
| 2008-09-19 | Warren JFK (OH) ** | 62 | Newton Falls (OH) | 6 | | |
| 2008-09-19 | Zanesville (OH) ** | 49 | Warren Local (OH) | 3 | | |
| 2008-09-19 | Greencastle Atrium (PA) ** | 21 | Hershey (PA) | 7 | | |
| 2008-09-19 | Schenley (PA) ** | 22 | Oliver (PA) | 20 | | |
| 2008-09-19 | State College (PA) | 55 | John Marshall ** | 0 | | |
| 2008-09-19 | Hampton (TN) | 34 | Unaka (TN) ** | 3 | | |
| 2008-09-19 | Alleghany (VA) | 10 | Bath County (VA) ** | 7 | | |
| 2008-09-19 | Auburn (VA) | 45 | Craig County (VA) ** | 29 | | |
| 2008-09-19 | Bland (VA) ** | 21 | Eastern Montgomery (VA) | 0 | | |
| 2008-09-19 | Briar Woods (VA) ** | 57 | Hedgesville | 3 | | |
| 2008-09-19 | Eastern View (VA) | 12 | Clarke County (VA) ** | 7 | | |
| 2008-09-19 | Floyd County (VA) | 28 | Ft. Chiswell (VA) ** | 25 | | |
| 2008-09-19 | James Wood (VA) ** | 16 | Millbrook (VA) | 6 | | |
| 2008-09-19 | Narrows (VA) ** | 40 | Twin Valley (VA) | 7 | | |
| 2008-09-19 | Richlands (VA) | 41 | Graham (VA) ** | 20 | | |
| 2008-09-19 | Robinson (VA) ** | 63 | Anacostia (DC) | 14 | | |
| 2008-09-19 | Skyline (VA) ** | 36 | Woodstock Central (VA) | 0 | | |
| 2008-09-19 | Twin Springs (VA) | 35 | St. Paul (VA) ** | 7 | | |
| 2008-09-19 | Warren County (VA) | 7 | Sherando (VA) ** | 5 | | |
| 2008-09-19 | Woodberry Forest (VA) ** | 40 | Kettle Run (VA) | 7 | | |
| 2008-09-20 | Parkersburg Catholic ** | 14 | Calhoun County | 0 | | |
| 2008-09-20 | Magnolia | 35 | Tolsia ** | 27 | | |
| 2008-09-20 | Bishop Walsh (MD) ** | 47 | Rappahannock County (VA) | 16 | | |
| 2008-09-20 | Bellaire (OH) ** | 40 | Steubenville Central (OH) | 20 | | |
| 2008-09-20 | Reedsville Eastern (OH) | 49 | Hannan ** | 8 | | |
| 2008-09-20 | Shadyside (OH) | 21 | Bishop Rosecrans (OH) ** | 12 | | |
| 2008-09-20 | Linsly (WV) ** | 19 | Kiski (PA) | 12 | | |