| Date | Score | Score | ||||
| 2008-11-07 | Buffalo | 38 | Wahama ** | 19 | ||
| 2008-11-07 | Hundred | 22 | Hannan ** | 14 | ||
| 2008-11-07 | Madonna | 41 | Cameron ** | 6 | ||
| 2008-11-07 | Man ** | 28 | Iaeger | 0 | ||
| 2008-11-07 | Matewan | 60 | Burch ** | 0 | ||
| 2008-11-07 | Midland Trail ** | 41 | PikeView | 28 | ||
| 2008-11-07 | Moorefield | 47 | Tygarts Valley ** | 6 | ||
| 2008-11-07 | Mt. Hope ** | 50 | Sherman | 27 | ||
| 2008-11-07 | Paden City ** | 20 | Bishop Donahue | 6 | ||
| 2008-11-07 | Richwood | 21 | Gilmer County ** | 12 | ||
| 2008-11-07 | St. Marys ** | 47 | Calhoun County | 13 | ||
| 2008-11-07 | Valley-Fayette | 37 | Williamson ** | 0 | ||
| 2008-11-07 | Williamstown ** | 28 | Parkersburg Catholic | 7 | ||
| 2008-11-07 | Frankfort | 34 | Hampshire ** | 0 | ||
| 2008-11-07 | Greenbrier West ** | 26 | Pendleton County | 20 | 2 OT | |
| 2008-11-07 | James Monroe | 34 | Summers County ** | 6 | ||
| 2008-11-07 | Magnolia ** | 29 | Grafton | 24 | ||
| 2008-11-07 | Oak Glen | 43 | Tolsia ** | 26 | ||
| 2008-11-07 | Oak Hill | 46 | Mt. View ** | 12 | ||
| 2008-11-07 | Petersburg | 30 | East Hardy ** | 29 | ||
| 2008-11-07 | Philip Barbour | 38 | Tucker County ** | 35 | ||
| 2008-11-07 | Pt. Pleasant ** | 17 | Chapmanville | 7 | ||
| 2008-11-07 | Roane County ** | 55 | Ritchie County | 26 | ||
| 2008-11-07 | Scott | 25 | Lincoln County ** | 19 | ||
| 2008-11-07 | Wayne ** | 49 | Logan | 14 | ||
| 2008-11-07 | Weir ** | 41 | Tyler Consolidated | 21 | ||
| 2008-11-07 | Wyoming East | 34 | Liberty-Raleigh ** | 6 | ||
| 2008-11-07 | Bridgeport ** | 41 | North Marion | 7 | ||
| 2008-11-07 | Elkins ** | 34 | Buckhannon-Upshur | 32 | ||
| 2008-11-07 | Fairmont Sr. ** | 30 | East Fairmont | 7 | ||
| 2008-11-07 | Hedgesville ** | 10 | Berkeley Springs | 7 | ||
| 2008-11-07 | Hurricane ** | 54 | Brooke | 15 | ||
| 2008-11-07 | Jefferson ** | 42 | Washington | 7 | ||
| 2008-11-07 | Martinsburg | 56 | Eastern View (VA) ** | 14 | ||
| 2008-11-07 | Nitro ** | 35 | Princeton | 17 | ||
| 2008-11-07 | Parkersburg South ** | 34 | John Marshall | 14 | ||
| 2008-11-07 | Preston ** | 28 | Nicholas County | 14 | ||
| 2008-11-07 | Ripley | 10 | Ravenswood ** | 6 | ||
| 2008-11-07 | South Charleston | 29 | Bluefield ** | 21 | ||
| 2008-11-07 | Spring Valley ** | 27 | Woodrow Wilson | 14 | ||
| 2008-11-07 | Wheeling Park ** | 49 | Robert C. Byrd | 21 | ||
| 2008-11-07 | Winfield ** | 28 | Herbert Hoover | 6 | ||
| 2008-11-07 | Ballou (DC) | 38 | Anacostia (DC) ** | 0 | ||
| 2008-11-07 | McKinley (DC) ** | 2 | Eastern (DC) | 0 | ||
| 2008-11-07 | Woodson-Eastern (DC) | 53 | Spingarn (DC) ** | 6 | ||
| 2008-11-07 | Breathitt County (KY) ** | 49 | Shelby Valley (KY) | 22 | ||
| 2008-11-07 | Pike Central (KY) | 42 | Tug Valley ** | 26 | ||
| 2008-11-07 | Calvert (MD) ** | 31 | Mt. Ridge (MD) | 28 | ||
| 2008-11-07 | Smithburg (MD) | 20 | Boonsboro (MD) ** | 13 | ||
| 2008-11-07 | Bland (VA) | 29 | Grayson County (VA) ** | 14 | ||
| 2008-11-07 | Briar Woods (VA) | 61 | Freedom (VA) ** | 23 | ||
| 2008-11-07 | Broad Run (VA) | 39 | Park View-Sterling (VA) ** | 26 | ||
| 2008-11-07 | Craig County (VA) ** | 66 | Montcalm | 14 | ||
| 2008-11-07 | Ft. Chiswell (VA) ** | 20 | Narrows (VA) | 7 | ||
| 2008-11-07 | Galax (VA) | 34 | Big Creek ** | 28 | ||
| 2008-11-07 | Loudoun County (VA) | 27 | Heritage (VA) ** | 21 | ||
| 2008-11-07 | Madison County (VA) | 41 | Manassas Park (VA) ** | 13 | ||
| 2008-11-07 | Sherando (VA) ** | 43 | Kettle Run (VA) | 0 | ||
| 2008-11-08 | Fort Hill (MD) | 26 | Allegany (MD) ** | 22 | ||
| 2008-11-08 | Linganore (MD) | 31 | Urbana (MD) ** | 24 |