| Date | Score | Score | ||||
| 2009-11-06 | Bishop Donahue | 12 | Doddridge County ** | 7 | ||
| 2009-11-06 | Burch | 54 | Hannan ** | 20 | ||
| 2009-11-06 | Calhoun County ** | 14 | St. Marys | 12 | ||
| 2009-11-06 | Cameron | 13 | Valley-Wetzel ** | 6 | ||
| 2009-11-06 | East Hardy | 33 | Petersburg ** | 0 | ||
| 2009-11-06 | Gilbert ** | 30 | Tug Valley | 0 | ||
| 2009-11-06 | Iaeger ** | 44 | Trinity | 22 | ||
| 2009-11-06 | Madonna | 28 | Clay-Battelle ** | 2 | ||
| 2009-11-06 | Meadow Bridge | 40 | Big Creek ** | 0 | ||
| 2009-11-06 | Moorefield ** | 17 | Tygarts Valley | 0 | ||
| 2009-11-06 | Pendleton County | 36 | Bath County (VA) ** | 35 | ||
| 2009-11-06 | Richwood ** | 68 | Gilmer County | 26 | ||
| 2009-11-06 | Tucker County | 48 | Philip Barbour ** | 22 | ||
| 2009-11-06 | Valley-Fayette ** | 42 | Williamson | 14 | ||
| 2009-11-06 | Wahama | 58 | Buffalo ** | 22 | ||
| 2009-11-06 | Wheeling Central ** | 36 | Linsly (WV) | 35 | ||
| 2009-11-06 | Williamstown | 28 | Parkersburg Catholic ** | 14 | ||
| 2009-11-06 | Wirt County | 48 | South Harrison ** | 20 | ||
| 2009-11-06 | Bluefield ** | 49 | Robert C. Byrd | 14 | ||
| 2009-11-06 | Frankfort ** | 35 | Hampshire | 33 | ||
| 2009-11-06 | James Monroe ** | 42 | Summers County | 0 | ||
| 2009-11-06 | Keyser ** | 41 | Mt. Ridge (MD) | 14 | ||
| 2009-11-06 | Liberty-Raleigh | 34 | Wyoming East ** | 12 | ||
| 2009-11-06 | Magnolia | 25 | Grafton ** | 3 | ||
| 2009-11-06 | Oak Hill ** | 40 | Mt. View | 17 | ||
| 2009-11-06 | PikeView ** | 68 | Midland Trail | 14 | ||
| 2009-11-06 | Poca | 36 | Tolsia ** | 6 | ||
| 2009-11-06 | Pt. Pleasant | 48 | Chapmanville ** | 20 | ||
| 2009-11-06 | Roane County | 32 | Ritchie County ** | 13 | ||
| 2009-11-06 | Scott ** | 32 | Lincoln County | 0 | ||
| 2009-11-06 | Sherman ** | 32 | Mt. Hope | 19 | ||
| 2009-11-06 | Tyler Consolidated ** | 40 | Weir | 10 | ||
| 2009-11-06 | Wayne | 34 | Logan ** | 14 | ||
| 2009-11-06 | Bridgeport | 53 | North Marion ** | 15 | ||
| 2009-11-06 | Brooke | 14 | Musselman ** | 13 | ||
| 2009-11-06 | Buckhannon-Upshur ** | 35 | Elkins | 12 | ||
| 2009-11-06 | Cabell Midland | 24 | Hurricane ** | 7 | ||
| 2009-11-06 | Capital ** | 28 | Huntington | 20 | ||
| 2009-11-06 | Fairmont Sr. | 31 | East Fairmont ** | 6 | ||
| 2009-11-06 | George Washington | 54 | St. Albans ** | 29 | ||
| 2009-11-06 | Hedgesville | 28 | Berkeley Springs ** | 27 | ||
| 2009-11-06 | Jefferson | 24 | Washington ** | 0 | ||
| 2009-11-06 | Nicholas County ** | 42 | Preston | 6 | ||
| 2009-11-06 | Parkersburg South | 48 | John Marshall ** | 20 | ||
| 2009-11-06 | Princeton ** | 49 | Woodrow Wilson | 6 | ||
| 2009-11-06 | Ripley ** | 10 | Ravenswood | 7 | ||
| 2009-11-06 | South Charleston | 45 | Riverside ** | 6 | ||
| 2009-11-06 | Spring Valley ** | 34 | Winfield | 14 | ||
| 2009-11-06 | Bishop Walsh (MD) | 48 | Hancock (MD) ** | 22 | ||
| 2009-11-06 | Boonsboro (MD) ** | 28 | Smithburg (MD) | 15 | ||
| 2009-11-06 | North Hagerstown (MD) ** | 44 | South Hagerstown (MD) | 0 | ||
| 2009-11-06 | Northern Garrett County (MD) ** | 14 | Southern Garrett County (MD) | 12 | ||
| 2009-11-06 | Williamsport (MD) | 20 | Clear Spring (MD) ** | 6 | ||
| 2009-11-06 | State College (PA) | 46 | Chambersburg (PA) ** | 14 | ||
| 2009-11-06 | Briar Woods (VA) ** | 35 | Dominion (VA) | 12 | ||
| 2009-11-06 | Byrd (VA) | 22 | Alleghany (VA) ** | 21 | ||
| 2009-11-06 | Ervinton (VA) ** | 42 | Montcalm | 14 | ||
| 2009-11-06 | Galax (VA) ** | 35 | Narrows (VA) | 6 | ||
| 2009-11-06 | Handley (VA) ** | 18 | James Wood (VA) | 10 | ||
| 2009-11-06 | Hurley (VA) | 54 | Twin Valley (VA) ** | 6 | ||
| 2009-11-06 | Loudoun Countty (VA) ** | 38 | Potomac Falls (VA) | 0 | ||
| 2009-11-06 | Park View-Sterling (VA) ** | 37 | Freedom (VA) | 0 | ||
| 2009-11-06 | Rappahannock County (VA) | 36 | Hundred ** | 14 | ||
| 2009-11-06 | Richlands (VA) ** | 54 | Grundy (VA) | 13 | ||
| 2009-11-06 | Sherando (VA) ** | 9 | Millbrook (VA) | 6 | ||
| 2009-11-07 | Man ** | 56 | Matewan | 6 | ||
| 2009-11-07 | Fort Hill (MD) ** | 17 | Allegany (MD) | 7 | ||
| 2009-11-07 | Linganore (MD) ** | 42 | Urbana (MD) | 14 | ||
| 2009-11-07 | Thomas Johnson (MD) | 34 | Frederick (MD) ** | 10 |