| Date |
|
Score |
|
Score |
|
|
| 2010-08-26 | Wheeling Central ** | 56 | Bellaire (OH) | 7 | | |
| 2010-08-26 | Capital | 47 | Riverside ** | 7 | | |
| 2010-08-26 | George Washington ** | 55 | Woodrow Wilson | 12 | | |
| 2010-08-26 | Morgantown | 41 | Wheeling Park ** | 7 | | |
| 2010-08-26 | Charlotte Country Day Sch (NC) | 28 | T.W.Andrews (NC) ** | 12 | | |
| 2010-08-26 | Bridgeport (OH) | 40 | Steubenville Central (OH) ** | 7 | | |
| 2010-08-26 | Steubenville (OH) ** | 36 | Inkster (MI) | 0 | | |
| 2010-08-26 | Wellsville (OH) | 13 | Toronto (OH) ** | 12 | | |
| 2010-08-27 | Bishop Donahue | 57 | Cameron ** | 0 | | |
| 2010-08-27 | Buffalo | 32 | Gilbert ** | 7 | | |
| 2010-08-27 | Calhoun County | 52 | Gilmer County ** | 38 | | |
| 2010-08-27 | Doddridge County | 18 | South Harrison ** | 0 | | |
| 2010-08-27 | East Hardy ** | 46 | Rappahannock County (VA) | 6 | | |
| 2010-08-27 | Fayetteville ** | 47 | Oak Hill | 20 | | |
| 2010-08-27 | Matewan | 47 | Wyoming East ** | 21 | | |
| 2010-08-27 | Notre Dame | 52 | Hundred ** | 22 | | |
| 2010-08-27 | Pendleton County ** | 35 | Tygarts Valley | 6 | | |
| 2010-08-27 | Pocahontas County | 24 | Tucker County ** | 8 | | |
| 2010-08-27 | Richwood ** | 34 | Webster County | 0 | | |
| 2010-08-27 | St. Marys ** | 52 | Ritchie County | 36 | | |
| 2010-08-27 | Van | 34 | Paden City ** | 6 | | |
| 2010-08-27 | Williamson ** | 41 | Hannan | 26 | | |
| 2010-08-27 | Williamstown | 41 | Tyler Consolidated ** | 0 | | |
| 2010-08-27 | Wirt County ** | 12 | Parkersburg Catholic | 7 | | |
| 2010-08-27 | Bluefield | 48 | Graham (VA) ** | 0 | | |
| 2010-08-27 | Braxton County ** | 32 | Lincoln | 0 | | |
| 2010-08-27 | Chapmanville | 45 | Sissonville ** | 6 | | |
| 2010-08-27 | Grafton | 30 | Philip Barbour ** | 3 | | |
| 2010-08-27 | Greenbrier West ** | 53 | Shady Spring | 14 | | |
| 2010-08-27 | Independence ** | 29 | Midland Trail | 20 | | |
| 2010-08-27 | James Monroe ** | 46 | Narrows (VA) | 8 | | |
| 2010-08-27 | Magnolia | 53 | Tolsia ** | 0 | | |
| 2010-08-27 | Petersburg ** | 34 | Clay-Battelle | 8 | | |
| 2010-08-27 | PikeView ** | 47 | Summers County | 24 | | |
| 2010-08-27 | Poca ** | 34 | Nitro | 6 | | |
| 2010-08-27 | Ravenswood | 23 | Herbert Hoover ** | 8 | | |
| 2010-08-27 | River View ** | 50 | Mt. View | 18 | | |
| 2010-08-27 | Tug Valley | 22 | Sherman ** | 21 | | |
| 2010-08-27 | Wayne | 26 | Keyser ** | 12 | | |
| 2010-08-27 | Westside | 20 | Liberty-Raleigh ** | 19 | | |
| 2010-08-27 | Bridgeport ** | 10 | Buckhannon-Upshur | 7 | | |
| 2010-08-27 | Brooke ** | 39 | Parkersburg | 17 | | |
| 2010-08-27 | Elkins ** | 43 | East Fairmont | 33 | | |
| 2010-08-27 | Fairmont Sr. | 28 | Robert C. Byrd ** | 21 | | |
| 2010-08-27 | Greenbrier East | 24 | Lincoln County ** | 22 | | |
| 2010-08-27 | Hampshire | 14 | Preston ** | 6 | | |
| 2010-08-27 | Hedgesville ** | 20 | Washington | 6 | | |
| 2010-08-27 | Hurricane ** | 42 | Winfield | 14 | | |
| 2010-08-27 | Lewis County | 34 | Liberty-Harrison ** | 20 | | |
| 2010-08-27 | Logan ** | 55 | Man | 18 | | |
| 2010-08-27 | Martinsburg | 27 | S. Jackson-Manassas (VA) ** | 21 | | |
| 2010-08-27 | Nicholas County ** | 36 | Clay County | 0 | | |
| 2010-08-27 | Parkersburg South ** | 43 | Ripley | 16 | | |
| 2010-08-27 | South Charleston | 44 | Huntington ** | 7 | | |
| 2010-08-27 | Spring Valley | 28 | Princeton ** | 19 | | |
| 2010-08-27 | University ** | 38 | North Marion | 12 | | |
| 2010-08-27 | Winfield | 38 | Ripley ** | 30 | | |
| 2010-08-27 | Archbishop Carroll (DC) | 28 | Calvin Coolidge (DC) ** | 0 | | |
| 2010-08-27 | Allen Central (KY) | 42 | Jenkins (KY) ** | 0 | | |
| 2010-08-27 | Bethlehem (KY) ** | 55 | Eminence (KY) | 18 | | |
| 2010-08-27 | Betsy Layne (KY) ** | 52 | Burch | 6 | | |
| 2010-08-27 | East Ridge (KY) ** | 31 | Shelby Valley (KY) | 6 | | |
| 2010-08-27 | Mcgoffin County (KY) ** | 46 | South Floyd (KY) | 26 | | |
| 2010-08-27 | Perry Co. Central (KY) ** | 22 | Casey County (KY) | 21 | | |
| 2010-08-27 | Pike Central (KY) ** | 47 | Phelps (KY) | 14 | | |
| 2010-08-27 | Prestonsburg (KY) | 63 | Paintsville (KY) ** | 7 | | |
| 2010-08-27 | Alexander (OH) ** | 31 | Reedsville Eastern (OH) | 6 | | |
| 2010-08-27 | Barnesville (OH) | 21 | John Glenn (OH) ** | 13 | | |
| 2010-08-27 | Cambridge (OH) | 32 | John Marshall ** | 26 | 1 OT | |
| 2010-08-27 | Danville (OH) ** | 46 | Grove City Christian (OH) | 0 | | |
| 2010-08-27 | East Liverpool (OH) ** | 16 | Beaver Local (OH) | 10 | | |
| 2010-08-27 | Edison Local (OH) ** | 36 | Oak Glen | 12 | | |
| 2010-08-27 | Fort Frye (OH) | 38 | River (OH) ** | 14 | | |
| 2010-08-27 | Gallia Academy (OH) | 36 | Athens (OH) ** | 21 | | |
| 2010-08-27 | Green (OH) ** | 40 | Manchester (OH) | 6 | | |
| 2010-08-27 | Harrison Central (OH) | 47 | Claymont (OH) ** | 37 | | |
| 2010-08-27 | Indian Creek (OH) | 33 | Weir ** | 0 | | |
| 2010-08-27 | Marietta (OH) | 28 | Morgan (OH) ** | 7 | | |
| 2010-08-27 | Martins Ferry (OH) | 28 | Buckeye Local (OH) ** | 13 | | |
| 2010-08-27 | Minford (OH) ** | 35 | South Point (OH) | 12 | | |
| 2010-08-27 | Mogadone (OH) ** | 21 | Linsly (WV) | 7 | | |
| 2010-08-27 | Monroe Central (OH) | 34 | Columbiana (OH) ** | 28 | | |
| 2010-08-27 | Nelsonville-York (OH) ** | 14 | Trimble (OH) | 6 | | |
| 2010-08-27 | Oak Hill (OH) ** | 35 | Chesapeake (OH) | 7 | | |
| 2010-08-27 | Portsmouth Notre Dame (OH) | 33 | Fayetteville-Perry (OH) ** | 0 | | |
| 2010-08-27 | Portsmouth West (OH) | 46 | Fairland (OH) ** | 16 | | |
| 2010-08-27 | RIver Valley-Bidwell (OH) | 27 | Federal Hocking (OH) ** | 6 | | |
| 2010-08-27 | Sciotoville Community (OH) | 25 | South Gallia (OH) ** | 8 | | |
| 2010-08-27 | Shadyside (OH) | 42 | Beallsville (OH) ** | 0 | | |
| 2010-08-27 | Shenandoah (OH) ** | 19 | Frontier (OH) | 16 | | |
| 2010-08-27 | St. Clairsville (OH) ** | 34 | Crestview (OH) | 24 | | |
| 2010-08-27 | Stasburg-Franklin (OH) ** | 52 | St.John Central (OH) | 0 | | |
| 2010-08-27 | Symmes Valley (OH) | 39 | Racine Southern (OH) ** | 13 | | |
| 2010-08-27 | Unioto (OH) ** | 33 | Vinton County (OH) | 7 | | |
| 2010-08-27 | Warren Local (OH) ** | 42 | Belpre (OH) | 12 | | |
| 2010-08-27 | Waterford (OH) | 40 | Miller (OH) ** | 20 | | |
| 2010-08-27 | Zanesville (OH) | 41 | Newark (OH) ** | 7 | | |
| 2010-08-27 | Broad Run (VA) | 21 | Fauquier (VA) ** | 0 | | |
| 2010-08-27 | Clarke County (VA) ** | 49 | Berkeley Springs | 7 | | |
| 2010-08-27 | Loudoun County (VA) | 14 | Musselman ** | 13 | | |
| 2010-08-27 | Potomac Falls (VA) | 14 | Jefferson ** | 7 | | |
| 2010-08-27 | Richlands (VA) | 31 | Gate City (VA) ** | 0 | | |
| 2010-08-27 | Roanoke Catholic (VA) ** | 42 | Carlisle (VA) | 32 | | |
| 2010-08-27 | Sherando (VA) ** | 35 | Park View-Sterling (VA) | 32 | | |
| 2010-08-28 | Madonna ** | 47 | Valley-Wetzel | 13 | | |
| 2010-08-28 | Moorefield | 48 | Bishop Walsh (MD) ** | 40 | | |
| 2010-08-28 | Alleghany (VA) ** | 26 | Covington (VA) | 6 | | |
| 2010-08-28 | Briar Woods (VA) | 10 | Millbrook (VA) ** | 8 | | |
| 2010-08-28 | Craig County (VA) ** | 42 | Auburn (VA) | 6 | | |
| 2010-08-28 | Eastern Montgomery (VA) | 27 | Bath County (VA) ** | 20 | | |
| 2010-08-28 | Grundy (VA) ** | 51 | Twin Valley (VA) | 6 | | |
| 2010-08-28 | Hurley (VA) | 40 | Ervinton (VA) ** | 0 | | |
| 2010-08-28 | Spotswood (VA) | 42 | East Rockingham (VA) ** | 0 | | |