| Date |
|
Score |
|
Score |
|
|
| 2010-09-16 | Martinsburg ** | 8 | Briar Woods (VA) | 7 | | |
| 2010-09-16 | Middletown (MD) | 34 | Boonsboro (MD) ** | 0 | | |
| 2010-09-16 | Thomas Johnson (MD) | 20 | Century (MD) ** | 7 | | |
| 2010-09-16 | Urbana (MD) ** | 37 | Jefferson | 0 | | |
| 2010-09-16 | Charlotte Country Day Sch (NC) ** | 41 | Bluefield | 14 | | |
| 2010-09-16 | Broad Run (VA) | 42 | Wilson (DC) ** | 6 | | |
| 2010-09-16 | Forest Park (VA) | 40 | S. Jackson-Manassas (VA) ** | 12 | | |
| 2010-09-16 | John Paul The Great (VA) | 61 | Sidwell Friends (MD) ** | 6 | | |
| 2010-09-17 | Bishop Donahue ** | 72 | St.John Central (OH) | 13 | | |
| 2010-09-17 | Buffalo ** | 46 | Sciotoville Community (OH) | 13 | | |
| 2010-09-17 | Clay-Battelle ** | 40 | Hundred | 0 | | |
| 2010-09-17 | East Hardy | 20 | Pocahontas County ** | 13 | | |
| 2010-09-17 | Matewan ** | 22 | Westside | 20 | | |
| 2010-09-17 | Meadow Bridge | 46 | Fayetteville ** | 41 | | |
| 2010-09-17 | Paden City | 1 | Gilmer County ** | 0 | | |
| 2010-09-17 | Pendleton County | 49 | Mt. Hope ** | 30 | | |
| 2010-09-17 | Richwood | 16 | Midland Trail ** | 14 | | |
| 2010-09-17 | Tucker County ** | 44 | Moorefield | 23 | | |
| 2010-09-17 | Valley-Wetzel ** | 37 | Notre Dame | 21 | | |
| 2010-09-17 | Van ** | 20 | Gilbert | 16 | | |
| 2010-09-17 | Wahama ** | 48 | Belpre (OH) | 0 | | |
| 2010-09-17 | Williamstown ** | 48 | South Harrison | 7 | | |
| 2010-09-17 | Wirt County ** | 49 | Doddridge County | 8 | | |
| 2010-09-17 | Braxton County | 46 | Ritchie County ** | 13 | | |
| 2010-09-17 | Chapmanville ** | 69 | Poca | 66 | | |
| 2010-09-17 | Frankfort | 36 | Berkeley Springs ** | 19 | | |
| 2010-09-17 | Grafton ** | 22 | Weir | 3 | | |
| 2010-09-17 | Greenbrier West | 46 | Oak Hill ** | 20 | | |
| 2010-09-17 | Herbert Hoover | 60 | Sherman ** | 20 | | |
| 2010-09-17 | James Monroe ** | 24 | PikeView | 0 | | |
| 2010-09-17 | Keyser ** | 19 | Northern Garrett County (MD) | 6 | | |
| 2010-09-17 | Liberty-Harrison | 34 | Philip Barbour ** | 14 | | |
| 2010-09-17 | Liberty-Raleigh | 44 | Mt. View ** | 0 | | |
| 2010-09-17 | Magnolia | 41 | River (OH) ** | 0 | | |
| 2010-09-17 | Oak Glen | 42 | Buckeye Local (OH) ** | 13 | | |
| 2010-09-17 | Pt. Pleasant ** | 48 | South Point (OH) | 8 | | |
| 2010-09-17 | River View ** | 33 | Man | 21 | | |
| 2010-09-17 | Roane County | 53 | Webster County ** | 0 | | |
| 2010-09-17 | Scott | 45 | Sissonville ** | 24 | | |
| 2010-09-17 | Shady Spring ** | 37 | Independence | 7 | | |
| 2010-09-17 | Tolsia ** | 69 | Tug Valley | 44 | | |
| 2010-09-17 | Wyoming East ** | 19 | Summers County | 14 | | |
| 2010-09-17 | Brooke | 49 | Woodrow Wilson ** | 32 | | |
| 2010-09-17 | Capital | 43 | Hurricane ** | 18 | | |
| 2010-09-17 | Fairmont Sr. ** | 26 | Preston | 7 | | |
| 2010-09-17 | George Washington | 35 | Spring Valley ** | 14 | | |
| 2010-09-17 | Hedgesville ** | 20 | James Wood (VA) | 16 | | |
| 2010-09-17 | Lewis County ** | 35 | Lincoln | 3 | | |
| 2010-09-17 | Lincoln County | 16 | Ripley ** | 10 | | |
| 2010-09-17 | Morgantown | 50 | East Fairmont ** | 0 | | |
| 2010-09-17 | Musselman ** | 45 | Washington | 20 | | |
| 2010-09-17 | Nicholas County ** | 33 | Greenbrier East | 14 | | |
| 2010-09-17 | North Marion | 40 | Buckhannon-Upshur ** | 7 | | |
| 2010-09-17 | Parkersburg ** | 51 | Huntington | 21 | | |
| 2010-09-17 | Parkersburg South | 13 | Winfield ** | 3 | | |
| 2010-09-17 | Riverside | 28 | Cabell Midland ** | 14 | | |
| 2010-09-17 | Robert C. Byrd | 35 | Bridgeport ** | 24 | | |
| 2010-09-17 | St. Albans | 6 | Nitro ** | 0 | | |
| 2010-09-17 | University ** | 41 | Elkins | 9 | | |
| 2010-09-17 | Wheeling Park ** | 28 | John Marshall | 18 | | |
| 2010-09-17 | Ballou (DC) | 27 | Calvin Coolidge (DC) ** | 6 | | |
| 2010-09-17 | BIshop Brossart (KY) ** | 34 | Eminence (KY) | 13 | | |
| 2010-09-17 | Mcgoffin County (KY) | 48 | Betsy Layne (KY) ** | 12 | | |
| 2010-09-17 | Perry Co. Central (KY) ** | 28 | Logan | 20 | | |
| 2010-09-17 | Pike Central (KY) | 61 | Knott County Central (KY) ** | 0 | | |
| 2010-09-17 | Prestonsburg (KY) ** | 35 | Pikeville (KY) | 13 | | |
| 2010-09-17 | Sheldon Clark (KY) ** | 12 | Lawrence County (KY) | 6 | | |
| 2010-09-17 | South Floyd (KY) | 36 | Williamson ** | 30 | | |
| 2010-09-17 | Clear Spring (MD) | 52 | Hancock (MD) ** | 12 | | |
| 2010-09-17 | Mont St. Joseph (MD) | 14 | Fort Hill (MD) ** | 10 | | |
| 2010-09-17 | Mt. Ridge (MD) ** | 23 | Allegany (MD) | 19 | | |
| 2010-09-17 | Southern Garrett County (MD) ** | 35 | Hampshire | 14 | | |
| 2010-09-17 | Alexander (OH) ** | 41 | Frontier (OH) | 26 | | |
| 2010-09-17 | Athens (OH) | 19 | Chillicothe (OH) ** | 10 | | |
| 2010-09-17 | Barnesville (OH) ** | 39 | Buckeye Trail (OH) | 7 | | |
| 2010-09-17 | Beallsville (OH) ** | 42 | Cameron | 19 | | |
| 2010-09-17 | Bridgeport (OH) ** | 39 | Bishop Rosecrans (OH) | 13 | | |
| 2010-09-17 | Cambridge (OH) | 22 | Claymont (OH) ** | 21 | | |
| 2010-09-17 | Dawson-Bryant (OH) | 38 | Trimble (OH) ** | 27 | | |
| 2010-09-17 | Edison Local (OH) | 37 | Tyler Consolidated ** | 6 | | |
| 2010-09-17 | Fayetteville-Perry (OH) ** | 26 | Gallatin County (KY) | 14 | | |
| 2010-09-17 | Gallia Academy (OH) | 34 | Marietta (OH) ** | 21 | | |
| 2010-09-17 | Indian Creek (OH) ** | 14 | Union Local (OH) | 12 | | |
| 2010-09-17 | Martins Ferry (OH) | 32 | Harrison Central (OH) ** | 14 | | |
| 2010-09-17 | McKinley (OH) | 13 | Beaver Local (OH) ** | 6 | | |
| 2010-09-17 | Monroe Central (OH) ** | 49 | Caldwell (OH) | 13 | | |
| 2010-09-17 | Portsmouth (OH) ** | 47 | Warren Local (OH) | 7 | | |
| 2010-09-17 | Racine Southern (OH) ** | 21 | Federal Hocking (OH) | 14 | | |
| 2010-09-17 | Reedsville Eastern (OH) | 26 | Waterford (OH) ** | 13 | | |
| 2010-09-17 | Shadyside (OH) | 56 | Shenandoah (OH) ** | 6 | | |
| 2010-09-17 | South Gallia (OH) ** | 24 | Miller (OH) | 20 | | |
| 2010-09-17 | St. Clairsville (OH) ** | 54 | Bellaire (OH) | 7 | | |
| 2010-09-17 | Steubenville (OH) ** | 14 | St. John's (DC) | 0 | | |
| 2010-09-17 | Steubenville Central (OH) | 26 | Toronto (OH) ** | 6 | | |
| 2010-09-17 | Valley (OH) | 35 | Chesapeake (OH) ** | 13 | | |
| 2010-09-17 | Vinton County (OH) ** | 18 | Waverly (OH) | 17 | | |
| 2010-09-17 | Wheelersburg (OH) | 42 | Fairland (OH) ** | 22 | | |
| 2010-09-17 | Perry Traditional Acad. (PA) ** | 40 | Peabody (PA) | 6 | | |
| 2010-09-17 | United (PA) ** | 28 | Purchase Line (PA) | 8 | | |
| 2010-09-17 | E.C.Glass (VA) ** | 20 | William Fleming (VA) | 17 | | |
| 2010-09-17 | Gate City (VA) ** | 44 | Lebanon (VA) | 0 | | |
| 2010-09-17 | Roanoke Catholic (VA) ** | 45 | Montcalm | 0 | | |
| 2010-09-17 | Sherando (VA) | 21 | Loudoun County (VA) ** | 14 | | |
| 2010-09-17 | Virginia (VA) | 42 | Graham (VA) ** | 31 | | |
| 2010-09-17 | Walker (VA) ** | 26 | Ervinton (VA) | 6 | | |
| 2010-09-18 | Parkersburg Catholic ** | 31 | Calhoun County | 0 | | |
| 2010-09-18 | Friendship Collegiate (DC) | 26 | Wheeling Central ** | 16 | | |
| 2010-09-18 | East Ridge (KY) ** | 49 | Hurley (VA) | 28 | | |
| 2010-09-18 | Phelps (KY) ** | 32 | Twin Valley (VA) | 20 | | |
| 2010-09-18 | St. James (MD) ** | 39 | Bishop Walsh (MD) | 0 | | |
| 2010-09-18 | East Liverpool (OH) | 21 | Zanesville (OH) ** | 17 | | |
| 2010-09-18 | Fairfield Christian Acad. (OH) ** | 35 | Green (OH) | 12 | | |
| 2010-09-18 | Jefferson Area (OH) | 44 | Grove City Christian (OH) ** | 12 | | |
| 2010-09-18 | North East (PA) | 6 | Fairview (PA) ** | 0 | | |
| 2010-09-18 | Schenley (PA) ** | 24 | Oliver (PA) | 0 | | |
| 2010-09-18 | Alleghany (VA) | 35 | Bath County (VA) ** | 13 | | |
| 2010-09-18 | Clarke County (VA) ** | 49 | East Rockingham (VA) | 0 | | |
| 2010-09-18 | Eastern Montgomery (VA) | 38 | Craig County (VA) ** | 13 | | |
| 2010-09-18 | Giles (VA) | 42 | Narrows (VA) ** | 14 | | |
| 2010-09-18 | Liberty (VA) | 43 | Potomac Falls (VA) ** | 8 | | |
| 2010-09-18 | Pound (VA) ** | 41 | Jenkins (KY) | 0 | | |
| 2010-09-18 | Linsly (WV) ** | 40 | Kiski Prep (PA) | 0 | | |