| Date |
|
Score |
|
Score |
|
|
| 2010-09-24 | Bishop Donahue | 58 | Burch ** | 0 | | |
| 2010-09-24 | Buffalo | 1 | Hannan ** | 0 | | |
| 2010-09-24 | Doddridge County ** | 35 | Gilmer County | 16 | | |
| 2010-09-24 | East Hardy ** | 47 | Tygarts Valley | 16 | | |
| 2010-09-24 | Fayetteville | 42 | Valley-Fayette ** | 6 | | |
| 2010-09-24 | Hundred ** | 30 | Paden City | 12 | | |
| 2010-09-24 | Madonna | 47 | Cameron ** | 7 | | |
| 2010-09-24 | Meadow Bridge ** | 44 | Pendleton County | 30 | | |
| 2010-09-24 | Mt. Hope | 36 | Midland Trail ** | 0 | | |
| 2010-09-24 | Parkersburg Catholic ** | 1 | Trinity | 0 | | |
| 2010-09-24 | Pocahontas County | 39 | Richwood ** | 6 | | |
| 2010-09-24 | St. Marys | 34 | Moorefield ** | 13 | | |
| 2010-09-24 | Van | 45 | Williamson ** | 12 | | |
| 2010-09-24 | Wahama | 42 | Waterford (OH) ** | 21 | | |
| 2010-09-24 | Williamstown | 78 | Calhoun County ** | 8 | | |
| 2010-09-24 | Berkeley Springs ** | 32 | Petersburg | 7 | | |
| 2010-09-24 | Bluefield ** | 64 | Oak Hill | 14 | | |
| 2010-09-24 | Chapmanville | 35 | Logan ** | 20 | | |
| 2010-09-24 | Frankfort ** | 54 | Northern Garrett County (MD) | 38 | | |
| 2010-09-24 | Greenbrier West ** | 49 | Summers County | 12 | | |
| 2010-09-24 | Herbert Hoover | 34 | Clay County ** | 8 | | |
| 2010-09-24 | James Monroe | 55 | Scott ** | 19 | | |
| 2010-09-24 | Liberty-Harrison ** | 28 | Notre Dame | 6 | | |
| 2010-09-24 | Liberty-Raleigh ** | 36 | Sherman | 17 | | |
| 2010-09-24 | Lincoln | 42 | Webster County ** | 6 | | |
| 2010-09-24 | PikeView | 13 | Shady Spring ** | 7 | | |
| 2010-09-24 | Pt. Pleasant ** | 48 | Vinton County (OH) | 0 | | |
| 2010-09-24 | Ravenswood ** | 55 | Tyler Consolidated | 14 | | |
| 2010-09-24 | River View ** | 44 | Gilbert | 6 | | |
| 2010-09-24 | Roane County | 30 | Braxton County ** | 23 | | |
| 2010-09-24 | Tug Valley | 57 | Jenkins (KY) ** | 0 | | |
| 2010-09-24 | Wayne | 66 | Sissonville ** | 21 | | |
| 2010-09-24 | Westside ** | 50 | Independence | 44 | | |
| 2010-09-24 | Wyoming East | 43 | Mt. View ** | 24 | | |
| 2010-09-24 | Bridgeport ** | 41 | East Fairmont | 0 | | |
| 2010-09-24 | Brooke ** | 40 | Wheeling Park | 14 | | |
| 2010-09-24 | Buckhannon-Upshur ** | 23 | Grafton | 20 | | |
| 2010-09-24 | Cabell Midland | 17 | Lincoln County ** | 6 | | |
| 2010-09-24 | George Washington | 41 | Princeton ** | 6 | | |
| 2010-09-24 | Huntington | 21 | Riverside ** | 20 | | |
| 2010-09-24 | Hurricane | 34 | Greenbrier East ** | 14 | | |
| 2010-09-24 | Martinsburg ** | 42 | Fort Hill (MD) | 10 | | |
| 2010-09-24 | Nicholas County ** | 28 | Lewis County | 20 | | |
| 2010-09-24 | Nitro | 17 | Ripley ** | 3 | | |
| 2010-09-24 | North Marion ** | 27 | Preston | 7 | | |
| 2010-09-24 | Parkersburg | 43 | Woodrow Wilson ** | 14 | | |
| 2010-09-24 | Robert C. Byrd ** | 41 | Elkins | 16 | | |
| 2010-09-24 | South Charleston | 35 | Capital ** | 14 | | |
| 2010-09-24 | Spring Valley | 34 | St. Albans ** | 14 | | |
| 2010-09-24 | University | 35 | Hedgesville ** | 28 | | |
| 2010-09-24 | Winfield ** | 69 | Tolsia | 12 | | |
| 2010-09-24 | McKinley (DC) ** | 21 | Roosevelt (DC) | 0 | | |
| 2010-09-24 | Betsy Layne (KY) ** | 59 | Phelps (KY) | 14 | | |
| 2010-09-24 | East Ridge (KY) ** | 76 | South Floyd (KY) | 44 | | |
| 2010-09-24 | Eminence (KY) ** | 61 | Bracken County (KY) | 0 | | |
| 2010-09-24 | Lawrence County (KY) ** | 61 | East Carter (KY) | 0 | | |
| 2010-09-24 | Perry Co. Central (KY) ** | 50 | Letcher County Central (KY) | 23 | | |
| 2010-09-24 | Prestonsburg (KY) ** | 20 | Sheldon Clark (KY) | 6 | | |
| 2010-09-24 | Allegany (MD) ** | 25 | Keyser | 20 | | |
| 2010-09-24 | Catoctin (MD) | 39 | Boonsboro (MD) ** | 0 | | |
| 2010-09-24 | Clear Spring (MD) | 41 | Clay-Battelle ** | 24 | | |
| 2010-09-24 | Forestville M.A. (MD) | 22 | Calvin Coolidge (DC) ** | 19 | | |
| 2010-09-24 | Hancock (MD) ** | 48 | Carson Long M.A. (PA) | 0 | | |
| 2010-09-24 | Mt. Ridge (MD) | 35 | Hampshire ** | 21 | | |
| 2010-09-24 | Southern Garrett County (MD) | 40 | Rappahannock County (VA) ** | 0 | | |
| 2010-09-24 | Thomas Johnson (MD) | 20 | Westminster (MD) ** | 7 | | |
| 2010-09-24 | Charlotte Country Day Sch (NC) | 14 | Ravenscroft (NC) ** | 12 | | |
| 2010-09-24 | Athens (OH) ** | 22 | Parkersburg South | 7 | | |
| 2010-09-24 | Barnesville (OH) | 48 | Shenandoah (OH) ** | 18 | | |
| 2010-09-24 | Beaver Local (OH) | 19 | Oak Glen ** | 14 | | |
| 2010-09-24 | Buckeye Trail (OH) ** | 30 | St.John Central (OH) | 7 | | |
| 2010-09-24 | Caldwell (OH) ** | 39 | River (OH) | 16 | | |
| 2010-09-24 | East Liverpool (OH) | 28 | Struthers (OH) ** | 21 | | |
| 2010-09-24 | Edison Local (OH) ** | 40 | Harrison Central (OH) | 28 | | |
| 2010-09-24 | Federal Hocking (OH) | 24 | Belpre (OH) ** | 7 | | |
| 2010-09-24 | Frontier (OH) ** | 48 | Beallsville (OH) | 42 | 1 OT | |
| 2010-09-24 | Green (OH) ** | 35 | Fayetteville-Perry (OH) | 12 | | |
| 2010-09-24 | Grove City Christian (OH) ** | 73 | Horizon Science Adac.(OH) | 0 | | |
| 2010-09-24 | Indian Creek (OH) | 41 | Buckeye Local (OH) ** | 12 | | |
| 2010-09-24 | Jackson (OH) ** | 42 | Warren Local (OH) | 7 | | |
| 2010-09-24 | Logan (OH) ** | 13 | Marietta (OH) | 0 | | |
| 2010-09-24 | Martins Ferry (OH) ** | 49 | Union Local (OH) | 7 | | |
| 2010-09-24 | Meigs (OH) | 35 | Racine Southern (OH) ** | 0 | | |
| 2010-09-24 | Monroe Central (OH) | 35 | Fort Frye (OH) ** | 14 | | |
| 2010-09-24 | Portsmouth West (OH) ** | 34 | Chesapeake (OH) | 6 | | |
| 2010-09-24 | Reedsville Eastern (OH) ** | 42 | South Gallia (OH) | 0 | | |
| 2010-09-24 | Sciotoville Community (OH) | 32 | Manchester (OH) ** | 0 | | |
| 2010-09-24 | Shadyside (OH) ** | 35 | Bishop Rosecrans (OH) | 7 | | |
| 2010-09-24 | Sheridan (OH) | 42 | Cambridge (OH) ** | 6 | | |
| 2010-09-24 | St. Clairsville (OH) ** | 38 | Nelsonville-York (OH) | 7 | | |
| 2010-09-24 | Toronto (OH) ** | 25 | Valley-Wetzel | 3 | | |
| 2010-09-24 | Trimble (OH) | 44 | Miller (OH) ** | 6 | | |
| 2010-09-24 | Valley (OH) | 48 | South Point (OH) ** | 14 | | |
| 2010-09-24 | Wellston (OH) | 18 | Fairland (OH) ** | 6 | | |
| 2010-09-24 | Zanesville (OH) | 49 | John Marshall ** | 20 | | |
| 2010-09-24 | Marion Center (PA) | 17 | Purchase Line (PA) ** | 14 | | |
| 2010-09-24 | Perry Traditional Acad. (PA) | 35 | Oliver (PA) ** | 0 | | |
| 2010-09-24 | Gate City (VA) ** | 45 | Appalachia (VA) | 8 | | |
| 2010-09-24 | Hurley (VA) | 37 | Montcalm ** | 0 | | |
| 2010-09-24 | Marion (VA) ** | 29 | Graham (VA) | 25 | | |
| 2010-09-24 | Pulaski County (VA) ** | 14 | William Fleming (VA) | 10 | | |
| 2010-09-24 | Sherando (VA) ** | 59 | Jefferson | 20 | | |
| 2010-09-24 | Warren County (VA) | 19 | James Wood (VA) ** | 0 | | |
| 2010-09-25 | Washington ** | 34 | John Paul The Great (VA) | 7 | | |
| 2010-09-25 | Bellaire (OH) ** | 32 | Steubenville Central (OH) | 13 | | |
| 2010-09-25 | Bridgeport (OH) ** | 24 | Wheeling Central | 7 | | |
| 2010-09-25 | Fairfield Christian Acad. (OH) ** | 28 | Portsmouth Notre Dame (OH) | 7 | | |
| 2010-09-25 | Steubenville (OH) | 35 | Morgantown ** | 7 | | |
| 2010-09-25 | Alleghany (VA) ** | 28 | Cave Spring (VA) | 27 | 1 OT | |
| 2010-09-25 | Briar Woods (VA) | 35 | Freedom (VA) ** | 3 | | |
| 2010-09-25 | Broad Run (VA) | 42 | Park View-Sterling (VA) ** | 21 | | |
| 2010-09-25 | Clarke County (VA) | 35 | Woodstock Central (VA) ** | 8 | | |
| 2010-09-25 | Dominion (VA) | 49 | Potomac Falls (VA) ** | 14 | | |
| 2010-09-25 | Galax (VA) ** | 30 | Craig County (VA) | 21 | | |
| 2010-09-25 | Liberty (VA) ** | 28 | Loudoun County (VA) | 6 | | |
| 2010-09-25 | Narrows (VA) | 20 | Auburn (VA) ** | 14 | | |
| 2010-09-25 | Pound (VA) | 21 | Twin Valley (VA) ** | 12 | | |
| 2010-09-25 | Woodbridge (VA) ** | 30 | S. Jackson-Manassas (VA) | 22 | | |
| 2010-09-25 | Linsly (WV) | 35 | Gilmour Academy (OH) ** | 6 | | |