| Date |
|
Score |
|
Score |
|
|
| 2010-10-14 | Thomas Johnson (MD) ** | 28 | Tuscarora (MD) | 6 | | |
| 2010-10-15 | Clay-Battelle ** | 34 | Cameron | 0 | | |
| 2010-10-15 | Fayetteville ** | 29 | Mt. Hope | 14 | | |
| 2010-10-15 | Man | 54 | Gilbert ** | 0 | | |
| 2010-10-15 | Matewan | 50 | Burch ** | 6 | | |
| 2010-10-15 | Meadow Bridge ** | 44 | Summers County | 0 | | |
| 2010-10-15 | Moorefield ** | 49 | East Hardy | 19 | | |
| 2010-10-15 | Pendleton County ** | 33 | Tucker County | 6 | | |
| 2010-10-15 | Pocahontas County ** | 46 | Tygarts Valley | 6 | | |
| 2010-10-15 | St. Marys | 41 | Gilmer County ** | 18 | | |
| 2010-10-15 | Van ** | 34 | Hannan | 6 | | |
| 2010-10-15 | Wahama ** | 39 | South Gallia (OH) | 0 | | |
| 2010-10-15 | Wirt County | 13 | Williamstown ** | 7 | | |
| 2010-10-15 | Bluefield ** | 24 | William Fleming (VA) | 8 | | |
| 2010-10-15 | Braxton County ** | 28 | Tyler Consolidated | 0 | | |
| 2010-10-15 | Clay County ** | 34 | Sherman | 7 | | |
| 2010-10-15 | Frankfort ** | 35 | Petersburg | 13 | | |
| 2010-10-15 | Greenbrier West | 58 | Webster County ** | 0 | | |
| 2010-10-15 | Independence ** | 20 | Liberty-Raleigh | 8 | | |
| 2010-10-15 | Keyser | 28 | Shady Spring ** | 21 | | |
| 2010-10-15 | Liberty-Harrison | 46 | South Harrison ** | 36 | | |
| 2010-10-15 | Magnolia ** | 35 | Robert C. Byrd | 7 | | |
| 2010-10-15 | Poca ** | 34 | Winfield | 29 | | |
| 2010-10-15 | Ravenswood ** | 27 | Pt. Pleasant | 24 | | |
| 2010-10-15 | Ritchie County | 42 | Doddridge County ** | 14 | | |
| 2010-10-15 | River View | 50 | Midland Trail ** | 14 | | |
| 2010-10-15 | Roane County | 54 | Calhoun County ** | 6 | | |
| 2010-10-15 | Scott | 20 | Mt. View ** | 6 | | |
| 2010-10-15 | Tug Valley | 26 | Williamson ** | 14 | | |
| 2010-10-15 | Wayne | 20 | Tolsia ** | 12 | | |
| 2010-10-15 | Westside ** | 58 | Wyoming East | 28 | | |
| 2010-10-15 | Bridgeport | 27 | Grafton ** | 6 | | |
| 2010-10-15 | Capital ** | 40 | Spring Valley | 14 | | |
| 2010-10-15 | East Fairmont | 27 | Preston ** | 6 | | |
| 2010-10-15 | Fairmont Sr. ** | 28 | Elkins | 21 | | |
| 2010-10-15 | Greenbrier East | 27 | James Monroe ** | 6 | | |
| 2010-10-15 | Hurricane ** | 46 | Princeton | 13 | | |
| 2010-10-15 | Jefferson | 35 | Hedgesville ** | 21 | | |
| 2010-10-15 | Lewis County | 21 | Philip Barbour ** | 11 | | |
| 2010-10-15 | Logan | 14 | Herbert Hoover ** | 7 | | |
| 2010-10-15 | Martinsburg ** | 52 | Park View-Sterling (VA) | 3 | | |
| 2010-10-15 | Morgantown ** | 44 | Brooke | 20 | | |
| 2010-10-15 | Musselman ** | 35 | Hampshire | 0 | | |
| 2010-10-15 | Nicholas County ** | 62 | Oak Hill | 7 | | |
| 2010-10-15 | Parkersburg ** | 53 | Cabell Midland | 35 | | |
| 2010-10-15 | Ripley ** | 24 | Sissonville | 23 | | |
| 2010-10-15 | Riverside | 41 | Nitro ** | 3 | | |
| 2010-10-15 | South Charleston | 56 | St. Albans ** | 7 | | |
| 2010-10-15 | University | 48 | John Marshall ** | 14 | | |
| 2010-10-15 | Washington ** | 39 | East Rockingham (VA) | 8 | | |
| 2010-10-15 | Woodrow Wilson ** | 24 | Huntington | 20 | | |
| 2010-10-15 | Calvin Coolidge (DC) | 16 | Roosevelt (DC) ** | 0 | | |
| 2010-10-15 | Red Lion Chr. Acad. (DE) ** | 61 | Allegany (MD) | 35 | | |
| 2010-10-15 | Allen Central (KY) | 50 | South Floyd (KY) ** | 44 | | |
| 2010-10-15 | Harlan County (KY) | 50 | Perry Co. Central (KY) ** | 7 | | |
| 2010-10-15 | Hazard (KY) ** | 57 | Jenkins (KY) | 0 | | |
| 2010-10-15 | Paintsville (KY) | 18 | Phelps (KY) ** | 6 | | |
| 2010-10-15 | Pike Central (KY) ** | 60 | East Ridge (KY) | 13 | | |
| 2010-10-15 | Pikeville (KY) ** | 47 | Betsy Layne (KY) | 20 | | |
| 2010-10-15 | Rowan County (KY) ** | 34 | Lawrence County (KY) | 13 | | |
| 2010-10-15 | Boonsboro (MD) | 40 | Berkeley Springs ** | 3 | | |
| 2010-10-15 | Fort Hill (MD) | 25 | Southern Garrett County (MD) ** | 0 | | |
| 2010-10-15 | Hancock (MD) | 19 | Hundred ** | 16 | | |
| 2010-10-15 | Northern Garrett County (MD) ** | 26 | Mt. Ridge (MD) | 14 | | |
| 2010-10-15 | Charlotte Country Day Sch (NC) ** | 45 | Charlotte Christian (NC) | 21 | | |
| 2010-10-15 | Alexander (OH) ** | 28 | Athens (OH) | 27 | | |
| 2010-10-15 | Bishop Rosecrans (OH) | 31 | Grove City Christian (OH) ** | 7 | | |
| 2010-10-15 | Bridgeport (OH) ** | 42 | Beallsville (OH) | 0 | | |
| 2010-10-15 | Buckeye Local (OH) | 40 | Union Local (OH) ** | 33 | | |
| 2010-10-15 | Cambridge (OH) ** | 24 | New Philadelphia (OH) | 14 | | |
| 2010-10-15 | Chesapeake (OH) ** | 35 | Fairland (OH) | 12 | | |
| 2010-10-15 | East Liverpool (OH) ** | 32 | Oak Glen | 12 | | |
| 2010-10-15 | Edison Local (OH) ** | 24 | Bellaire (OH) | 21 | | |
| 2010-10-15 | Frontier (OH) ** | 49 | Valley-Wetzel | 20 | | |
| 2010-10-15 | Indian Creek (OH) ** | 33 | Harrison Central (OH) | 6 | | |
| 2010-10-15 | Jackson (OH) | 33 | Marietta (OH) ** | 10 | | |
| 2010-10-15 | Manchester (OH) | 48 | Fayetteville-Perry (OH) ** | 10 | | |
| 2010-10-15 | Martins Ferry (OH) ** | 13 | St. Clairsville (OH) | 7 | | |
| 2010-10-15 | Miller (OH) ** | 23 | Federal Hocking (OH) | 6 | | |
| 2010-10-15 | Monroe Central (OH) ** | 21 | Barnesville (OH) | 6 | | |
| 2010-10-15 | Nelsonville-York (OH) | 42 | Vinton County (OH) ** | 6 | | |
| 2010-10-15 | Reedsville Eastern (OH) | 27 | Sciotoville Community (OH) ** | 7 | | |
| 2010-10-15 | Rock Hill (OH) | 35 | South Point (OH) ** | 28 | | |
| 2010-10-15 | Salem (OH) | 27 | Beaver Local (OH) ** | 7 | | |
| 2010-10-15 | Shadyside (OH) ** | 28 | Toronto (OH) | 8 | | |
| 2010-10-15 | Shenandoah (OH) | 37 | River (OH) ** | 13 | | |
| 2010-10-15 | St.John Central (OH) | 26 | Paden City ** | 20 | 3 OT | |
| 2010-10-15 | Trimble (OH) ** | 60 | Belpre (OH) | 7 | | |
| 2010-10-15 | Ursuline (OH) | 24 | Steubenville (OH) ** | 3 | | |
| 2010-10-15 | Warren Local (OH) | 17 | Chillicothe (OH) ** | 13 | | |
| 2010-10-15 | Waterford (OH) ** | 35 | Racine Southern (OH) | 6 | | |
| 2010-10-15 | Zanesville (OH) ** | 39 | Logan (OH) | 10 | | |
| 2010-10-15 | Brashear (PA) | 21 | Oliver (PA) ** | 20 | | |
| 2010-10-15 | Fairview (PA) ** | 14 | Girard (PA) | 12 | | |
| 2010-10-15 | Perry Traditional Acad. (PA) | 39 | Wheeling Central ** | 28 | | |
| 2010-10-15 | Craig County (VA) ** | 57 | Montcalm | 0 | | |
| 2010-10-15 | Gate City (VA) | 42 | Virginia (VA) ** | 13 | | |
| 2010-10-15 | Roanoke Catholic (VA) | 34 | Rappahannock County (VA) ** | 16 | | |
| 2010-10-16 | Bishop Donahue ** | 46 | Notre Dame | 13 | | |
| 2010-10-16 | Madonna ** | 51 | Purchase Line (PA) | 6 | | |
| 2010-10-16 | Parkersburg Catholic ** | 28 | Valley-Fayette | 0 | | |
| 2010-10-16 | Weir | 14 | Steubenville Central (OH) ** | 12 | | |
| 2010-10-16 | Wheeling Park ** | 55 | Lincoln County | 20 | | |
| 2010-10-16 | Woodson-Eastern (DC) | 20 | McKinley (DC) ** | 15 | | |
| 2010-10-16 | Clear Spring (MD) | 56 | Bishop Walsh (MD) ** | 24 | | |
| 2010-10-16 | Portsmouth Notre Dame (OH) ** | 23 | Green (OH) | 7 | | |
| 2010-10-16 | Alleghany (VA) | 35 | Lord Botetourt (VA) ** | 7 | | |
| 2010-10-16 | Bath County (VA) ** | 21 | McCluer (VA) | 0 | | |
| 2010-10-16 | Briar Woods (VA) ** | 46 | Potomac Falls (VA) | 6 | | |
| 2010-10-16 | Broad Run (VA) ** | 44 | Freedom (VA) | 13 | | |
| 2010-10-16 | Castlewood (VA) ** | 26 | Ervinton (VA) | 16 | | |
| 2010-10-16 | Clarke County (VA) | 34 | Mason (VA) ** | 0 | | |
| 2010-10-16 | Graham (VA) | 41 | Tazewell (VA) ** | 14 | | |
| 2010-10-16 | Handley (VA) | 24 | Sherando (VA) ** | 21 | | |
| 2010-10-16 | Hurley (VA) | 50 | Pound (VA) ** | 19 | | |
| 2010-10-16 | James Wood (VA) ** | 21 | Skyline (VA) | 10 | | |
| 2010-10-16 | John Paul The Great (VA) ** | 42 | Randolph-Macon Acad. (VA) | 0 | | |
| 2010-10-16 | Loudoun County (VA) | 27 | Dominion (VA) ** | 21 | 1 OT | |
| 2010-10-16 | Loudoun Valley (VA) | 44 | S. Jackson-Manassas (VA) ** | 31 | | |
| 2010-10-16 | Narrows (VA) | 20 | Bland (VA) ** | 13 | | |
| 2010-10-16 | St. Paul (VA) ** | 38 | Twin Valley (VA) | 8 | | |
| 2010-10-16 | Linsly (WV) ** | 64 | Buckeye Trail (OH) | 26 | | |