| Date |
|
Score |
|
Score |
|
|
| 2010-10-28 | Morgantown ** | 27 | University | 6 | | |
| 2010-10-28 | Perry Traditional Acad. (PA) | 40 | Westinghouse (PA) ** | 6 | | |
| 2010-10-29 | Burch | 54 | Ervinton (VA) ** | 20 | | |
| 2010-10-29 | Man ** | 28 | Buffalo | 8 | | |
| 2010-10-29 | Matewan ** | 59 | Mt. View | 20 | | |
| 2010-10-29 | Meadow Bridge | 34 | Van ** | 14 | | |
| 2010-10-29 | Parkersburg Catholic | 60 | Gilmer County ** | 12 | | |
| 2010-10-29 | Pendleton County ** | 31 | Moorefield | 23 | | |
| 2010-10-29 | Pocahontas County | 47 | Webster County ** | 0 | | |
| 2010-10-29 | Richwood | 22 | Summers County ** | 6 | | |
| 2010-10-29 | South Harrison | 42 | Lincoln ** | 20 | | |
| 2010-10-29 | Tucker County | 30 | Petersburg ** | 28 | | |
| 2010-10-29 | Tygarts Valley ** | 22 | Hundred | 14 | | |
| 2010-10-29 | Valley-Fayette ** | 34 | Midland Trail | 14 | | |
| 2010-10-29 | Valley-Wetzel ** | 26 | Paden City | 6 | | |
| 2010-10-29 | Wahama | 56 | Miller (OH) ** | 12 | | |
| 2010-10-29 | Williamstown | 48 | Ritchie County ** | 34 | | |
| 2010-10-29 | Wirt County | 37 | Mt. Hope ** | 14 | | |
| 2010-10-29 | Bluefield | 54 | James Monroe ** | 20 | | |
| 2010-10-29 | Braxton County | 45 | Calhoun County ** | 18 | | |
| 2010-10-29 | Greenbrier West | 35 | Fayetteville ** | 14 | | |
| 2010-10-29 | Herbert Hoover ** | 23 | Pt. Pleasant | 16 | | |
| 2010-10-29 | Independence | 26 | Wyoming East ** | 8 | | |
| 2010-10-29 | Keyser | 54 | Frankfort ** | 7 | | |
| 2010-10-29 | Liberty-Harrison ** | 14 | Grafton | 0 | | |
| 2010-10-29 | Magnolia | 7 | Oak Glen ** | 6 | | |
| 2010-10-29 | PikeView ** | 55 | Oak Hill | 17 | | |
| 2010-10-29 | Poca ** | 62 | Sissonville | 28 | | |
| 2010-10-29 | Ravenswood | 27 | St. Marys ** | 7 | | |
| 2010-10-29 | River View ** | 38 | Lincoln County | 22 | | |
| 2010-10-29 | Roane County | 31 | Philip Barbour ** | 0 | | |
| 2010-10-29 | Scott | 46 | Sherman ** | 14 | | |
| 2010-10-29 | Shady Spring ** | 27 | Liberty-Raleigh | 24 | | |
| 2010-10-29 | Tyler Consolidated ** | 36 | Clay County | 22 | | |
| 2010-10-29 | Wayne | 16 | Chapmanville ** | 14 | | |
| 2010-10-29 | Westside ** | 58 | Gilbert | 14 | | |
| 2010-10-29 | Bridgeport | 21 | Fairmont Sr. ** | 13 | | |
| 2010-10-29 | Brooke ** | 69 | John Marshall | 13 | | |
| 2010-10-29 | Buckhannon-Upshur | 49 | Preston ** | 12 | | |
| 2010-10-29 | Capital | 34 | Parkersburg ** | 7 | | |
| 2010-10-29 | Elkins | 42 | North Marion ** | 28 | | |
| 2010-10-29 | George Washington ** | 61 | Greenbrier East | 7 | | |
| 2010-10-29 | Huntington | 43 | Princeton ** | 14 | | |
| 2010-10-29 | Hurricane ** | 55 | Logan | 0 | | |
| 2010-10-29 | Martinsburg ** | 35 | Musselman | 14 | | |
| 2010-10-29 | Parkersburg South ** | 41 | Wheeling Park | 14 | | |
| 2010-10-29 | Riverside ** | 25 | Woodrow Wilson | 19 | | |
| 2010-10-29 | Robert C. Byrd | 36 | Lewis County ** | 28 | | |
| 2010-10-29 | South Charleston ** | 60 | Cabell Midland | 27 | | |
| 2010-10-29 | Spring Valley ** | 41 | Nitro | 14 | | |
| 2010-10-29 | Washington ** | 33 | Hampshire | 28 | | |
| 2010-10-29 | Winfield ** | 32 | St. Albans | 14 | | |
| 2010-10-29 | Ballou (DC) | 18 | McKinley (DC) ** | 0 | | |
| 2010-10-29 | Berea (KY) | 48 | South Floyd (KY) ** | 38 | | |
| 2010-10-29 | Betsy Layne (KY) ** | 56 | Jenkins (KY) | 12 | | |
| 2010-10-29 | East Ridge (KY) ** | 44 | Tug Valley | 28 | | |
| 2010-10-29 | Lawrence County (KY) ** | 42 | Tolsia | 21 | | |
| 2010-10-29 | Perry Co. Central (KY) | 49 | Leslie County (KY) ** | 28 | | |
| 2010-10-29 | Pike Central (KY) | 31 | Prestonsburg (KY) ** | 24 | | |
| 2010-10-29 | Clear Spring (MD) ** | 41 | Randolph-Macon Acad. (VA) | 6 | | |
| 2010-10-29 | Fort Hill (MD) ** | 20 | Mt. Ridge (MD) | 16 | | |
| 2010-10-29 | North Hagerstown (MD) | 33 | Boonsboro (MD) ** | 20 | | |
| 2010-10-29 | Northern Garrett County (MD) | 42 | Berkeley Springs ** | 14 | | |
| 2010-10-29 | Thomas Johnson (MD) | 27 | Linganore (MD) ** | 14 | | |
| 2010-10-29 | Barnesville (OH) ** | 65 | Union Local (OH) | 28 | | |
| 2010-10-29 | Bridgeport (OH) | 55 | Cameron ** | 28 | | |
| 2010-10-29 | Brookfield (OH) ** | 34 | Beaver Local (OH) | 7 | | |
| 2010-10-29 | Buckeye Local (OH) | 40 | Weir ** | 0 | | |
| 2010-10-29 | Cambridge (OH) ** | 50 | Meadowbrook (OH) | 6 | | |
| 2010-10-29 | Chesapeake (OH) ** | 25 | Dawson-Bryant (OH) | 22 | | |
| 2010-10-29 | Fairland (OH) | 39 | Rock Hill (OH) ** | 38 | | |
| 2010-10-29 | Frontier (OH) | 40 | River (OH) ** | 17 | | |
| 2010-10-29 | Lockland (OH) ** | 53 | Fayetteville-Perry (OH) | 16 | | |
| 2010-10-29 | Marietta (OH) | 33 | Warren Local (OH) ** | 28 | | |
| 2010-10-29 | Martins Ferry (OH) ** | 28 | Bellaire (OH) | 0 | | |
| 2010-10-29 | Monroe Central (OH) ** | 41 | Buckeye Trail (OH) | 0 | | |
| 2010-10-29 | Nelsonville-York (OH) ** | 28 | Athens (OH) | 27 | | |
| 2010-10-29 | Oak Hill (OH) | 43 | Green (OH) ** | 33 | | |
| 2010-10-29 | Salem (OH) ** | 36 | East Liverpool (OH) | 6 | | |
| 2010-10-29 | Shadyside (OH) ** | 26 | Wheeling Central | 21 | | |
| 2010-10-29 | South Point (OH) | 58 | RIver Valley-Bidwell (OH) ** | 36 | | |
| 2010-10-29 | St. Clairsville (OH) | 37 | Harrison Central (OH) ** | 0 | | |
| 2010-10-29 | Steubenville (OH) ** | 36 | Cardinal OHara (NY) | 0 | | |
| 2010-10-29 | Symmes Valley (OH) ** | 53 | South Gallia (OH) | 12 | | |
| 2010-10-29 | Trimble (OH) ** | 52 | Federal Hocking (OH) | 12 | | |
| 2010-10-29 | Waterford (OH) ** | 49 | Belpre (OH) | 20 | | |
| 2010-10-29 | Wellston (OH) ** | 38 | Vinton County (OH) | 0 | | |
| 2010-10-29 | Chestnut Ridge (PA) ** | 43 | Allegany (MD) | 28 | | |
| 2010-10-29 | Fairview (PA) | 38 | Harborcreek (PA) ** | 0 | | |
| 2010-10-29 | Ligonier Valley (PA) ** | 54 | Purchase Line (PA) | 0 | | |
| 2010-10-29 | Oliver (PA) | 28 | Carrick (PA) ** | 20 | | |
| 2010-10-29 | Abingdon (VA) | 52 | Graham (VA) ** | 21 | | |
| 2010-10-29 | Bath County (VA) ** | 28 | James River (VA) | 0 | | |
| 2010-10-29 | Battlefield (VA) ** | 44 | S. Jackson-Manassas (VA) | 12 | | |
| 2010-10-29 | Blessed Sacrament-Huguenot (VA ** | 41 | Roanoke Catholic (VA) | 8 | | |
| 2010-10-29 | Broad Run (VA) ** | 52 | Potomac Falls (VA) | 24 | | |
| 2010-10-29 | Covington (VA) ** | 23 | Craig County (VA) | 14 | | |
| 2010-10-29 | Dominion (VA) | 24 | Park View-Sterling (VA) ** | 21 | | |
| 2010-10-29 | East Rockingham (VA) ** | 28 | East Hardy | 14 | | |
| 2010-10-29 | Gate City (VA) | 33 | Lee (VA) ** | 7 | | |
| 2010-10-29 | Grayson County (VA) | 54 | Narrows (VA) ** | 14 | | |
| 2010-10-29 | Halifax County (VA) | 1 | William Fleming (VA) ** | 0 | | |
| 2010-10-29 | Haysi (VA) | 42 | Twin Valley (VA) ** | 8 | | |
| 2010-10-29 | Honaker (VA) | 42 | Hurley (VA) ** | 7 | | |
| 2010-10-29 | John Paul The Great (VA) ** | 37 | Fishburne (VA) | 0 | | |
| 2010-10-29 | Loudoun County (VA) | 12 | Freedom (VA) ** | 0 | | |
| 2010-10-29 | Manassas Park (VA) ** | 21 | Clarke County (VA) | 14 | | |
| 2010-10-29 | Quantico (VA) ** | 43 | Rappahannock County (VA) | 6 | | |
| 2010-10-30 | Bishop Donahue ** | 21 | Madonna | 6 | | |
| 2010-10-30 | Montcalm ** | 47 | Hannan | 6 | | |
| 2010-10-30 | Notre Dame ** | 34 | Clay-Battelle | 20 | | |
| 2010-10-30 | Hancock (MD) ** | 22 | Our Lady of Lourdes (PA) | 14 | | |
| 2010-10-30 | Southern Garrett County (MD) | 49 | Bishop Walsh (MD) ** | 13 | | |
| 2010-10-30 | Beallsville (OH) | 48 | St.John Central (OH) ** | 0 | | |
| 2010-10-30 | Fairfield Christian Acad. (OH) ** | 56 | Grove City Christian (OH) | 20 | | |
| 2010-10-30 | Indian Creek (OH) ** | 19 | Edison Local (OH) | 7 | | |
| 2010-10-30 | LaBrae (OH) | 57 | Steubenville Central (OH) ** | 28 | | |
| 2010-10-30 | Portsmouth Notre Dame (OH) ** | 27 | Sciotoville Community (OH) | 0 | | |
| 2010-10-30 | Reedsville Eastern (OH) | 23 | Racine Southern (OH) ** | 13 | | |