| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 0000-00-00 | H | Madonna | Wheeling Central (6) | |||||
| 0000-00-00 | A | Madonna | Cameron (4) | |||||
| 0000-00-00 | H | Madonna | Wirt County (5) | |||||
| 2020-09-04 | H | W | Madonna | 50 | Wahama (6) | 20 | ||
| 2020-09-12 | A | L | Madonna | 20 | Scott (1) | 38 | ||
| 2020-09-18 | A | L | Madonna | 0 | Conotton Valley (OH) (4) | 48 | ||
| 2020-09-26 | A | W | Madonna | 34 | Steubenville Central (OH) (0) | 28 | ||
| 2020-10-03 | H | W | Madonna | 44 | Trinity (4) | 12 | ||
| 2020-10-10 | H | W | Madonna | 63 | Hundred (0) | 0 | ||
| 2020-10-17 | H | W | Madonna | 61 | Beallsville (OH) (1) | 20 | ||
| 2020-10-30 | H | W | Madonna | 30 | Mathews (OH) (3) | 0 | ||
| 2020-11-04 | H | W | Madonna | 32 | Bridgeport (OH) (2) | 14 | ||
| 2020-11-14 | A | L | Madonna | 0 | Greenbrier West (9) | 58 |