| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2020-09-04 | H | L | Preston | 0 | North Marion (7) | 32 | ||
| 2020-09-11 | A | L | Preston | 13 | John Marshall (4) | 46 | ||
| 2020-09-18 | A | L | Preston | 0 | Robert C. Byrd (10) | 41 | ||
| 2020-09-25 | A | L | Preston | 0 | Lewis County (5) | 1 | ||
| 2020-10-02 | H | L | Preston | 12 | Woodrow Wilson (1) | 21 | ||
| 2020-10-09 | A | W | Preston | 20 | Lewis County (5) | 12 | ||
| 2020-10-16 | A | L | Preston | 8 | Washington (3) | 35 | ||
| 2020-10-23 | A | L | Preston | 9 | University (3) | 42 | ||
| 2020-10-29 | H | W | Preston | 34 | Buckhannon-Upshur (0) | 0 | ||
| 2020-11-06 | H | W | Preston | 39 | Brooke (1) | 27 |