| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-20 | H | W | Villa Angela St. Joe (OH) | 44 | Cuyahoga Valley CA (OH) (0) | 12 | Hx 667 | |
| 2021-08-28 | H | W | Villa Angela St. Joe (OH) | 34 | Parma Heights Holy Name (OH) (0) | 16 | Hx 883 | |
| 2021-09-03 | A | W | Villa Angela St. Joe (OH) | 49 | Ashtabula Lakeside (OH) (0) | 26 | Hx 884 | |
| 2021-09-24 | A | L | Villa Angela St. Joe (OH) | 20 | Walsh Jesuit (OH) (0) | 50 | Hx 885 | |
| 2021-10-02 | H | W | Villa Angela St. Joe (OH) | 49 | Mentor Lake Catholic (OH) (0) | 20 | Hx 886 | |
| 2021-10-08 | A | W | Villa Angela St. Joe (OH) | 46 | Ursuline (OH) (1) | 28 | Hx 1186 | |
| 2021-10-15 | A | W | Villa Angela St. Joe (OH) | 56 | Chardon Notre Dame Latin (OH) (1) | 35 | Hx 887 |