| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-21 | A | W | Fairland (OH) | 28 | Portsmouth West (OH) (0) | 27 | Hx 998 | |
| 2021-08-27 | A | W | Fairland (OH) | 55 | Oak Hill (OH) (0) | 7 | Hx 999 | |
| 2021-09-03 | A | L | Fairland (OH) | 14 | Ironton (OH) (2) | 20 | Hx 1000 | |
| 2021-09-17 | H | W | Fairland (OH) | 41 | Rock Hill (OH) (0) | 6 | Hx 1001 | |
| 2021-09-24 | A | W | Fairland (OH) | 22 | Columbus (OH) (0) | 14 | Hx 1167 | |
| 2021-10-01 | A | W | Fairland (OH) | 41 | South Point (OH) (0) | 7 | Hx 1002 | |
| 2021-10-08 | H | W | Fairland (OH) | 15 | Portsmouth (OH) (0) | 14 | Hx 1003 | |
| 2021-10-15 | A | W | Fairland (OH) | 49 | Dawson-Bryant (OH) (1) | 16 | Hx 1004 | |
| 2021-10-22 | A | W | Fairland (OH) | 42 | Chesapeake (OH) (0) | 0 | Hx 1005 |