| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-20 | H | W | West Muskingum (OH) | 32 | John Glenn (OH) (0) | 0 | Hx 1144 | |
| 2021-08-27 | H | W | West Muskingum (OH) | 42 | Newcomerstown (OH) (0) | 21 | Hx 1145 | |
| 2021-09-04 | A | W | West Muskingum (OH) | 54 | Wahama (5) | 12 | Hx 1143 | |
| 2021-09-10 | A | W | West Muskingum (OH) | 35 | New Lexington (OH) (0) | 31 | Hx 1147 | |
| 2021-09-17 | A | L | West Muskingum (OH) | 7 | Maysville (OH) (0) | 31 | Hx 1148 | |
| 2021-09-24 | H | L | West Muskingum (OH) | 26 | Philo (OH) (0) | 40 | Hx 1149 | |
| 2021-10-01 | A | W | West Muskingum (OH) | 43 | Morgan (OH) (1) | 14 | Hx 1150 | |
| 2021-10-08 | H | W | West Muskingum (OH) | 44 | Crooksville (OH) (0) | 20 | Hx 1151 | |
| 2021-10-15 | A | L | West Muskingum (OH) | 33 | Coshocton (OH) (1) | 39 | Hx 1152 | |
| 2021-10-22 | H | L | West Muskingum (OH) | 20 | Meadowbrook (OH) (0) | 49 | Hx 1153 |