| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | L | West Greene (PA) | 20 | Cameron (9) | 26 | Hx 401 | |
| 2021-09-03 | H | L | West Greene (PA) | 0 | Burgettstown (PA) (0) | 20 | Hx 956 | |
| 2021-09-10 | A | W | West Greene (PA) | 38 | Bethlehem Center (PA) (0) | 30 | Hx 1029 | |
| 2021-09-17 | H | W | West Greene (PA) | 48 | California (PA) (0) | 22 | Hx 957 | |
| 2021-09-24 | A | W | West Greene (PA) | 48 | Avella (PA) (0) | 0 | Hx 958 | |
| 2021-10-01 | H | W | West Greene (PA) | 41 | Carmichaels (PA) (0) | 20 | Hx 959 | |
| 2021-10-08 | H | W | West Greene (PA) | 56 | Bentworth (PA) (0) | 0 | Hx 960 | |
| 2021-10-15 | A | W | West Greene (PA) | 28 | Monessen (PA) (0) | 14 | Hx 961 | |
| 2021-10-22 | H | W | West Greene (PA) | 56 | Jefferson-Morgan (PA) (0) | 8 | Hx 962 | |
| 2021-10-29 | A | W | West Greene (PA) | 31 | Mapletown (PA) (0) | 12 | Hx 963 |