| Date |
|
Score |
|
Score |
|
|
| 2021-11-19 | Williamstown | 44 | East Hardy ** | 24 | | |
| 2021-11-19 | Bluefield | 35 | North Marion ** | 21 | | |
| 2021-11-19 | Fairmont Sr. | 33 | Robert C. Byrd ** | 28 | | |
| 2021-11-19 | Independence ** | 22 | Roane County | 8 | | |
| 2021-11-19 | Cabell Midland | 46 | University ** | 21 | | |
| 2021-11-19 | Huntington ** | 29 | George Washington | 13 | | |
| 2021-11-19 | Martinsburg ** | 35 | Spring Valley | 6 | | |
| 2021-11-20 | Doddridge County ** | 14 | James Monroe | 0 | | |
| 2021-11-20 | Ritchie County ** | 34 | Mt. View | 6 | | |
| 2021-11-20 | Wheeling Central ** | 55 | Gilmer County | 0 | | |
| 2021-11-20 | Poca ** | 56 | Frankfort | 49 | | |
| 2021-11-20 | Bridgeport ** | 74 | Jefferson | 49 | | |
** denotes HOME team
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