| Date | Score | Score | ||||
| 2021-11-26 | Williamstown | 43 | Doddridge County ** | 0 | ||
| 2021-11-26 | Fairmont Sr. | 41 | Poca ** | 7 | ||
| 2021-11-26 | Independence ** | 34 | Bluefield | 20 | ||
| 2021-11-26 | Huntington ** | 37 | Cabell Midland | 15 | ||
| 2021-11-26 | Martinsburg ** | 21 | Bridgeport | 0 | ||
| 2021-11-27 | Ritchie County ** | 20 | Wheeling Central | 16 |