| Date | Score | Score | ||||
| 2022-11-25 | Doddridge County | 21 | Williamstown ** | 53 | Semifinals 2-11 | |
| 2022-11-25 | Wheeling Central | 7 | James Monroe ** | 27 | Semifinals 1-5 | |
| 2022-11-25 | North Marion | 19 | Independence ** | 58 | Semifinals 2-6 | |
| 2022-11-26 | Herbert Hoover | 17 | Frankfort ** | 10 | Semifinals 5-9 | |
| 2022-11-26 | Hurricane | 27 | Parkersburg South ** | 58 | Semifinals 1-4 | |
| 2022-11-26 | Martinsburg | 21 | Huntington ** | 28 | Semifinals 2-3 |