| Date | W/L | Team | Score | Opponent | Score | H/A | Game# |
| 2007-08-24 | W | Buffalo | 47 | Green (OH) | 8 | H | 538 |
| 2007-08-31 | W | Buffalo | 27 | Parkersburg Catholic | 8 | H | 361 |
| 2007-09-08 | L | Buffalo | 16 | Portsmouth Notre Dame (OH) | 21 | A | 539 |
| 2007-09-14 | L | Buffalo | 12 | East Sciotoville (OH) | 30 | A | 540 |
| 2007-09-21 | W | Buffalo | 32 | Poca | 21 | H | 362 |
| 2007-09-28 | W | Buffalo | 40 | Notre Dame | 16 | A | 457 |
| 2007-10-05 | L | Buffalo | 22 | Gilbert | 46 | H | 363 |
| 2007-10-12 | W | Buffalo | 24 | Wahama | 7 | H | 364 |
| 2007-10-19 | L | Buffalo | 22 | Fayetteville | 23 | A | 395 |
| 2007-10-26 | W | Buffalo | 20 | Matewan | 6 | A | 429 |