| Date | Score | Score | ||||
| 2024-10-31 | Bell (DC) | 36 | Ron Brown Prep (DC) ** | 0 | ||
| 2024-10-31 | Loudoun Valley (VA) ** | 70 | Dominion (VA) | 7 | ||
| 2024-11-01 | Hundred | 1 | Trinity ** | 0 | ||
| 2024-11-01 | Madonna ** | 21 | Oak Glen | 14 | ||
| 2024-11-01 | Magnolia ** | 46 | Valley-Wetzel | 32 | ||
| 2024-11-01 | Meadow Bridge | 57 | Buffalo ** | 28 | ||
| 2024-11-01 | Montcalm | 44 | Richwood ** | 6 | ||
| 2024-11-01 | Pendleton County ** | 41 | Moorefield | 40 | 2 OT | |
| 2024-11-01 | Pocahontas County ** | 47 | Tygarts Valley | 20 | ||
| 2024-11-01 | Sherman ** | 24 | Wirt County | 22 | ||
| 2024-11-01 | Summers County ** | 24 | Liberty-Raleigh | 12 | ||
| 2024-11-01 | Tucker County | 20 | Petersburg ** | 14 | ||
| 2024-11-01 | Tug Valley ** | 28 | Man | 19 | ||
| 2024-11-01 | Tyler Consolidated ** | 39 | St. Marys | 12 | ||
| 2024-11-01 | Van ** | 18 | Wyoming East | 7 | ||
| 2024-11-01 | Wahama ** | 63 | Gilmer County | 0 | ||
| 2024-11-01 | Webster County ** | 44 | Calhoun County | 13 | ||
| 2024-11-01 | Bluefield | 45 | Giles (VA) ** | 22 | ||
| 2024-11-01 | Chapmanville Regional | 14 | Mingo Central ** | 6 | ||
| 2024-11-01 | Clay County ** | 53 | Lincoln County | 12 | ||
| 2024-11-01 | Frankfort | 48 | Grafton ** | 6 | ||
| 2024-11-01 | Lincoln ** | 21 | Philip Barbour | 18 | ||
| 2024-11-01 | Midland Trail ** | 49 | Greenbrier West | 8 | ||
| 2024-11-01 | Poca ** | 20 | PikeView | 13 | ||
| 2024-11-01 | Roane County | 14 | North Marion ** | 6 | ||
| 2024-11-01 | Scott | 34 | Winfield ** | 14 | ||
| 2024-11-01 | South Harrison | 48 | Ravenswood ** | 6 | ||
| 2024-11-01 | Wayne | 55 | Logan ** | 20 | ||
| 2024-11-01 | Williamstown | 35 | Doddridge County ** | 13 | ||
| 2024-11-01 | Bridgeport | 56 | Fairmont Sr. ** | 28 | ||
| 2024-11-01 | Brooke ** | 27 | Weir | 14 | ||
| 2024-11-01 | East Fairmont ** | 42 | Lewis County | 21 | ||
| 2024-11-01 | Herbert Hoover | 45 | Hedgesville ** | 0 | ||
| 2024-11-01 | John Marshall | 34 | Pt. Pleasant ** | 21 | ||
| 2024-11-01 | Nitro | 67 | Sissonville ** | 0 | ||
| 2024-11-01 | Oak Hill ** | 19 | Woodrow Wilson | 14 | ||
| 2024-11-01 | Preston ** | 47 | Buckhannon-Upshur | 7 | ||
| 2024-11-01 | Princeton ** | 81 | Greenbrier East | 6 | ||
| 2024-11-01 | Ripley ** | 23 | Nicholas County | 15 | ||
| 2024-11-01 | Robert C. Byrd | 41 | Elkins ** | 40 | ||
| 2024-11-01 | Shady Spring ** | 35 | Westside | 14 | ||
| 2024-11-01 | Spring Valley ** | 61 | South Charleston | 7 | ||
| 2024-11-01 | St. Albans ** | 20 | Riverside | 7 | ||
| 2024-11-01 | Cabell Midland ** | 40 | Capital | 19 | ||
| 2024-11-01 | Huntington | 37 | Parkersburg ** | 12 | ||
| 2024-11-01 | Hurricane ** | 37 | George Washington | 21 | ||
| 2024-11-01 | Jefferson | 47 | Clarksburg (MD) ** | 21 | ||
| 2024-11-01 | Morgantown ** | 49 | University | 7 | ||
| 2024-11-01 | Spring Mills ** | 37 | Parkersburg South | 0 | ||
| 2024-11-01 | Washington | 28 | Musselman ** | 21 | ||
| 2024-11-01 | Knott County Central (KY) | 28 | East Ridge (KY) ** | 14 | ||
| 2024-11-01 | Magoffin County (KY) | 41 | Morgan County (KY) ** | 18 | ||
| 2024-11-01 | Phelps (KY) | 1 | Jenkins (KY) ** | 0 | ||
| 2024-11-01 | Century (MD) ** | 24 | Liberty (MD) | 23 | ||
| 2024-11-01 | Clear Spring (MD) ** | 50 | Hancock (MD) | 0 | ||
| 2024-11-01 | Frederick (MD) | 42 | Thomas Johnson (MD) ** | 0 | ||
| 2024-11-01 | Mt. Ridge (MD) | 56 | Keyser ** | 3 | ||
| 2024-11-01 | Northern Garrett County (MD) ** | 44 | Southern Garrett County (MD) | 0 | ||
| 2024-11-01 | Alleghany Highlands (VA) ** | 55 | James River (VA) | 0 | ||
| 2024-11-01 | Bath County (VA) ** | 63 | McCluer (VA) | 6 | ||
| 2024-11-01 | Castlewood (VA) ** | 20 | Hurley (VA) | 6 | ||
| 2024-11-01 | Eastern Montgomery (VA) | 38 | Twin Valley (VA) ** | 22 | ||
| 2024-11-01 | Eastside (VA) ** | 35 | River View | 0 | ||
| 2024-11-01 | Graham (VA) | 46 | Tazewell (VA) ** | 0 | ||
| 2024-11-01 | Grayson County (VA) | 35 | Wythe (VA) ** | 28 | ||
| 2024-11-01 | Grundy (VA) | 39 | Tolsia ** | 0 | ||
| 2024-11-01 | Handley (VA) | 48 | Millbrook (VA) ** | 27 | ||
| 2024-11-01 | Narrows (VA) ** | 28 | Craig County (VA) | 0 | ||
| 2024-11-01 | Pulaski County (VA) ** | 51 | Hidden Valley (VA) | 7 | ||
| 2024-11-01 | Rocktown (VA) ** | 63 | Mountain View (VA) | 0 | ||
| 2024-11-01 | Strasburg (VA) ** | 28 | Madison County (VA) | 7 | ||
| 2024-11-02 | Berkeley Springs | 35 | Braxton County ** | 29 | ||
| 2024-11-02 | Dunbar (DC) | 53 | Woodson (DC) ** | 0 | ||
| 2024-11-02 | Fort Hill (MD) | 39 | Allegany (MD) ** | 0 | ||
| 2024-11-02 | North Hagerstown (MD) | 41 | South Hagerstown (MD) ** | 14 | ||
| 2024-11-02 | Kiski Prep (PA) | 31 | Linsly (WV) ** | 28 | ||
| 2024-11-02 | Roanoke Catholic (VA) ** | 28 | Bland (VA) | 0 |