| Date | H/A | W/L | Team | Score | Opponent | Score | |||
| 2021-03-05 | A | L | Tygarts Valley | 43 | Clay-Battelle | 74 | 69 | ||
| 2021-03-08 | A | W | Tygarts Valley | 77 | Hundred | 25 | 188 | ||
| 2021-03-24 | H | W | Tygarts Valley | 73 | Union | 46 | 934 | ||
| 2021-03-26 | A | L | Tygarts Valley | 76 | Tucker County | 83 | 891 | ||
| 2021-03-30 | A | L | Tygarts Valley | 42 | Elkins | 61 | 1086 | ||
| 2021-03-31 | H | W | Tygarts Valley | 56 | Harman | 52 | 855 | ||
| 2021-04-03 | H | W | Tygarts Valley | 65 | Valley-Wetzel | 36 | 950 | ||
| 2021-04-05 | H | W | Tygarts Valley | 69 | Clay-Battelle | 61 | 798 | ||
| 2021-04-14 | H | W | Tygarts Valley | 75 | Hundred | 38 | 888 | ||
| 2021-04-15 | H | W | Tygarts Valley | 54 | Tucker County | 42 | 889 | ||
| 2021-04-20 | H | W | Tygarts Valley | 73 | Pocahontas County | 41 | 1198 | ||
| 2021-04-23 | A | L | Tygarts Valley | 32 | Pendleton County | 46 | 1236 | ||
| 2021-04-28 | A | L | Tygarts Valley | 36 | Tucker County | 53 | 1259 |