| Date | H/A | W/L | Team | Score | Opponent | Score | |||
| 2021-03-05 | A | L | Ripley | 53 | Nitro | 92 | 594 | ||
| 2021-03-06 | A | W | Ripley | 51 | Ravenswood | 34 | 595 | ||
| 2021-03-09 | H | W | Ripley | 74 | Pt. Pleasant | 71 | 596 | ||
| 2021-03-11 | H | L | Ripley | 50 | Winfield | 62 | 583 | ||
| 2021-03-13 | H | L | Ripley | 46 | Scott | 53 | 597 | ||
| 2021-03-18 | A | L | Ripley | 47 | Lincoln County | 56 | 573 | ||
| 2021-03-20 | H | W | Ripley | 67 | Riverside | 57 | 331 | ||
| 2021-03-22 | A | L | Ripley | 68 | Riverside | 70 | 332 | ||
| 2021-03-25 | A | W | Ripley | 54 | Calvary Baptist (WV) | 51 | 598 | ||
| 2021-03-27 | A | W | Ripley | 66 | East Fairmont | 44 | 88 | ||
| 2021-03-29 | H | L | Ripley | 48 | Lincoln County | 52 | 577 | ||
| 2021-04-03 | H | W | Ripley | 62 | Parkersburg Catholic | 41 | 600 | ||
| 2021-04-06 | A | L | Ripley | 63 | Pt. Pleasant | 74 | 601 | ||
| 2021-04-08 | H | L | Ripley | 59 | Nitro | 65 | 602 | ||
| 2021-04-10 | A | L | Ripley | 46 | Winfield | 71 | 592 | ||
| 2021-04-13 | H | W | Ripley | 67 | Ravenswood | 50 | 603 | ||
| 2021-04-15 | H | W | Ripley | 66 | Sissonville | 54 | 604 | ||
| 2021-04-21 | A | L | Ripley | 42 | Nitro | 60 | 1181 |