| Date | H/A | W/L | Team | Score | Opponent | Score | |||
| 2021-03-05 | A | W | Parkersburg Catholic | 67 | Wahama | 53 | 682 | ||
| 2021-03-06 | A | L | Parkersburg Catholic | 39 | Charleston Catholic | 70 | 54 | ||
| 2021-03-09 | H | W | Parkersburg Catholic | 71 | Wirt County | 54 | 683 | ||
| 2021-03-11 | H | L | Parkersburg Catholic | 43 | Ravenswood | 62 | 684 | ||
| 2021-03-13 | A | L | Parkersburg Catholic | 41 | Roane County | 72 | 761 | ||
| 2021-03-16 | H | L | Parkersburg Catholic | 53 | St. Marys | 66 | 685 | ||
| 2021-03-18 | A | L | Parkersburg Catholic | 25 | Williamstown | 79 | 686 | ||
| 2021-03-23 | H | L | Parkersburg Catholic | 53 | Tyler Consolidated | 82 | 687 | ||
| 2021-03-25 | A | L | Parkersburg Catholic | 40 | Ritchie County | 59 | 688 | ||
| 2021-03-27 | A | L | Parkersburg Catholic | 56 | St. Marys | 79 | 689 | ||
| 2021-03-30 | H | L | Parkersburg Catholic | 52 | Wahama | 63 | 690 | ||
| 2021-04-01 | A | L | Parkersburg Catholic | 52 | Wirt County | 71 | 691 | ||
| 2021-04-03 | A | L | Parkersburg Catholic | 41 | Ripley | 62 | 600 | ||
| 2021-04-06 | A | L | Parkersburg Catholic | 64 | Ravenswood | 69 | 692 | ||
| 2021-04-08 | A | L | Parkersburg Catholic | 43 | Calhoun County | 48 | LKC 15th | 1128 | |
| 2021-04-09 | H | L | Parkersburg Catholic | 56 | Williamstown | 84 | 693 | ||
| 2021-04-20 | A | L | Parkersburg Catholic | 40 | Wirt County | 43 | 1186 |