| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-20 | A | L | Millersport (OH) | 6 | Miami Valley Christian (OH) (1) | 38 | Hx 763 | |
| 2021-08-27 | A | L | Millersport (OH) | 0 | Bishop Rosecrans (OH) (1) | 43 | Hx 764 | |
| 2021-09-18 | H | L | Millersport (OH) | 20 | Miller (OH) (2) | 46 | Hx 765 | |
| 2021-09-24 | A | W | Millersport (OH) | 42 | Manchester (OH) (1) | 14 | Hx 1170 | |
| 2021-10-01 | A | W | Millersport (OH) | 45 | Federal Hocking (OH) (0) | 38 | Hx 732 | |
| 2021-10-09 | A | L | Millersport (OH) | 8 | Steubenville Central (OH) (3) | 41 | Hx 766 | |
| 2021-10-16 | H | W | Millersport (OH) | 44 | Federal Hocking (OH) (0) | 20 | Hx 733 | |
| 2021-10-22 | A | L | Millersport (OH) | 17 | Fairfield Christian Acad. (OH) (2) | 61 | Hx 1129 |