| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-20 | A | L | Steubenville Central (OH) | 0 | Mathews (OH) (6) | 6 | Hx 754 | |
| 2021-08-28 | H | W | Steubenville Central (OH) | 36 | Carrick (PA) (0) | 6 | Hx 809 | |
| 2021-09-04 | H | L | Steubenville Central (OH) | 13 | Edison Local (OH) (6) | 42 | Hx 810 | |
| 2021-09-11 | H | W | Steubenville Central (OH) | 24 | Bishop Rosecrans (OH) (1) | 13 | Hx 811 | |
| 2021-09-18 | H | L | Steubenville Central (OH) | 6 | Windham (OH) (1) | 36 | Hx 812 | |
| 2021-09-25 | H | L | Steubenville Central (OH) | 0 | Barnesville (OH) (5) | 50 | Hx 813 | |
| 2021-10-01 | A | L | Steubenville Central (OH) | 14 | Conotton Valley (OH) (5) | 20 | Hx 698 | |
| 2021-10-09 | H | W | Steubenville Central (OH) | 41 | Millersport (OH) (3) | 8 | Hx 766 | |
| 2021-10-15 | A | L | Steubenville Central (OH) | 7 | Madonna (6) | 28 | Hx 417 | |
| 2021-10-22 | A | L | Steubenville Central (OH) | 7 | Toronto (OH) (5) | 59 | Hx 814 |