| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | L | Ambridge (PA) | 14 | Wheeling Central (9) | 36 | Hx 451 | |
| 2021-09-03 | H | L | Ambridge (PA) | 0 | North Catholic (PA) (1) | 41 | Hx 935 | |
| 2021-09-10 | H | L | Ambridge (PA) | 6 | Laurel Valley (PA) (1) | 35 | Hx 936 | |
| 2021-09-17 | H | L | Ambridge (PA) | 0 | Aliquippa (PA) (1) | 56 | Hx 937 | |
| 2021-09-24 | H | L | Ambridge (PA) | 6 | Blackhawk (PA) (1) | 28 | Hx 938 | |
| 2021-10-01 | A | W | Ambridge (PA) | 35 | Hopewell (PA) (0) | 9 | Hx 939 | |
| 2021-10-08 | H | L | Ambridge (PA) | 7 | Avonworth (PA) (1) | 36 | Hx 940 | |
| 2021-10-15 | A | L | Ambridge (PA) | 0 | Central Valley (A) (1) | 44 | Hx 941 | |
| 2021-10-22 | H | W | Ambridge (PA) | 35 | Quaker Valley (PA) (0) | 12 | Hx 942 | |
| 2021-10-29 | A | L | Ambridge (PA) | 7 | Keystone Oaks (PA) (1) | 27 | Hx 943 |