| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 0000-00-00 | A | Wheeling Central | Ritchie County (13) | Hx 1313 | ||||
| 2021-08-27 | H | W | Wheeling Central | 36 | Ambridge (PA) (0) | 14 | Hx 451 | |
| 2021-09-04 | A | W | Wheeling Central | 52 | Tuscarawas Cent. Cath. (OH) (3) | 18 | Hx 452 | |
| 2021-09-11 | A | L | Wheeling Central | 7 | Bellaire (OH) (9) | 14 | Hx 453 | |
| 2021-09-17 | H | L | Wheeling Central | 21 | Shadyside (OH) (8) | 33 | Hx 454 | |
| 2021-09-24 | H | W | Wheeling Central | 49 | Man (4) | 21 | Hx 547 | |
| 2021-10-01 | H | W | Wheeling Central | 54 | Weir (2) | 27 | Hx 394 | |
| 2021-10-08 | A | W | Wheeling Central | 47 | Martins Ferry (OH) (1) | 6 | Hx 455 | |
| 2021-10-14 | A | L | Wheeling Central | 0 | St. Clairsville (OH) (4) | 35 | Hx 456 | |
| 2021-10-22 | H | W | Wheeling Central | 21 | Beaver Local (OH) (3) | 7 | Hx 457 | |
| 2021-11-04 | A | W | Wheeling Central | 55 | Oak Glen (2) | 17 | Hx 1169 | |
| 2021-11-13 | H | W | Wheeling Central | 35 | Moorefield (7) | 7 | 8-9 1st RD | Hx 1265 |
| 2021-11-20 | H | W | Wheeling Central | 55 | Gilmer County (7) | 0 | Quarterfinals | Hx 1303 |
| 2021-11-27 | A | L | Wheeling Central | 16 | Ritchie County (13) | 20 | Semifinals | Hx 1314 |