| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | L | Allderdice (PA) | 14 | North Allegheny (PA) (1) | 47 | Hx 950 | |
| 2021-09-10 | H | L | Allderdice (PA) | 20 | Altoona (PA) (1) | 28 | Hx 951 | |
| 2021-09-18 | A | L | Allderdice (PA) | 12 | Westinghouse (PA) (2) | 41 | Hx 952 | |
| 2021-09-23 | H | W | Allderdice (PA) | 27 | USO (PA) (0) | 15 | Hx 953 | |
| 2021-10-04 | A | W | Allderdice (PA) | 28 | Perry Traditional Acad. (PA) (0) | 14 | Hx 954 | |
| 2021-10-08 | A | L | Allderdice (PA) | 13 | Steubenville (OH) (7) | 48 | Hx 806 | |
| 2021-10-14 | H | L | Allderdice (PA) | 22 | Brashear (PA) (1) | 38 | Hx 955 |