| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-20 | H | W | Steubenville (OH) | 22 | Olentangy Liberty (OH) (0) | 7 | Hx 801 | |
| 2021-08-26 | H | W | Steubenville (OH) | 41 | New Philadelphia (OH) (1) | 7 | Hx 802 | |
| 2021-09-03 | H | W | Steubenville (OH) | 45 | Wheeling Park (3) | 16 | Hx 154 | |
| 2021-09-10 | H | W | Steubenville (OH) | 34 | USO (PA) (0) | 0 | Hx 803 | |
| 2021-09-17 | A | L | Steubenville (OH) | 7 | Dover (OH) (4) | 24 | Hx 804 | |
| 2021-09-24 | H | W | Steubenville (OH) | 26 | Linsly (WV) (4) | 17 | Hx 366 | |
| 2021-10-01 | H | L | Steubenville (OH) | 21 | St. Francis de Sales (OH) (1) | 36 | Hx 805 | |
| 2021-10-08 | H | W | Steubenville (OH) | 48 | Allderdice (PA) (2) | 13 | Hx 806 | |
| 2021-10-15 | H | W | Steubenville (OH) | 35 | Cardinal Mooney (OH) (0) | 14 | Hx 807 | |
| 2021-10-22 | H | W | Steubenville (OH) | 34 | University (OH) (0) | 20 | Hx 808 |