| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-20 | H | W | Gallia Academy (OH) | 22 | Meigs (OH) (0) | 19 | Hx 715 | |
| 2021-08-27 | A | W | Gallia Academy (OH) | 34 | Athens (OH) (0) | 0 | Hx 716 | |
| 2021-09-03 | A | L | Gallia Academy (OH) | 22 | Pt. Pleasant (8) | 26 | Hx 360 | |
| 2021-10-01 | H | L | Gallia Academy (OH) | 25 | Dawson-Bryant (OH) (1) | 34 | Hx 720 | |
| 2021-10-08 | A | W | Gallia Academy (OH) | 12 | Rock Hill (OH) (0) | 6 | Hx 721 | |
| 2021-10-15 | H | L | Gallia Academy (OH) | 0 | Ironton (OH) (2) | 43 | Hx 722 | |
| 2021-10-22 | A | W | Gallia Academy (OH) | 35 | South Point (OH) (0) | 13 | Hx 723 |