| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | H | L | Pt. Pleasant | 22 | Greenbrier East (6) | 32 | Hx 70 | |
| 2021-09-03 | H | W | Pt. Pleasant | 26 | Gallia Academy (OH) (2) | 22 | Hx 360 | |
| 2021-09-10 | H | W | Pt. Pleasant | 66 | Mingo Central (2) | 28 | Hx 325 | |
| 2021-09-17 | A | W | Pt. Pleasant | 42 | Oak Glen (2) | 7 | Hx 344 | |
| 2021-09-24 | A | W | Pt. Pleasant | 48 | Lincoln County (2) | 20 | Hx 128 | |
| 2021-10-08 | A | W | Pt. Pleasant | 35 | Keyser (4) | 33 | Hx 292 | |
| 2021-10-15 | A | W | Pt. Pleasant | 1 | Wyoming East (1) | 0 | Hx 361 | |
| 2021-10-22 | H | W | Pt. Pleasant | 41 | Man (4) | 14 | Hx 362 | |
| 2021-10-29 | H | W | Pt. Pleasant | 51 | Ripley (1) | 0 | Hx 177 | |
| 2021-11-05 | A | W | Pt. Pleasant | 17 | Winfield (5) | 14 | Hx 363 | |
| 2021-11-13 | H | L | Pt. Pleasant | 20 | Bluefield (7) | 44 | 3-14 1st RD | Hx 1278 |