| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-09-03 | A | L | South Hagerstown (MD) | 13 | Oak Dale (MD) (1) | 42 | Hx 924 | |
| 2021-09-10 | H | W | South Hagerstown (MD) | 39 | Tuscarora (MD) (0) | 0 | Hx 925 | |
| 2021-09-17 | A | L | South Hagerstown (MD) | 14 | Smithburg (MD) (3) | 15 | Hx 926 | |
| 2021-09-24 | H | W | South Hagerstown (MD) | 24 | Catoctin (MD) (0) | 22 | Hx 927 | |
| 2021-10-01 | A | L | South Hagerstown (MD) | 0 | Jefferson (10) | 64 | Hx 113 | |
| 2021-10-08 | A | W | South Hagerstown (MD) | 45 | Thomas Johnson (MD) (0) | 21 | Hx 928 | |
| 2021-10-14 | H | W | South Hagerstown (MD) | 33 | Williamsport (MD) (1) | 32 | Hx 929 | |
| 2021-10-22 | H | L | South Hagerstown (MD) | 21 | Boonsboro (MD) (2) | 34 | Hx 930 | |
| 2021-10-29 | A | W | South Hagerstown (MD) | 28 | North Hagerstown (MD) (2) | 7 | Hx 915 |