| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-09-03 | A | W | North Hagerstown (MD) | 19 | Thomas Johnson (MD) (0) | 6 | Hx 909 | |
| 2021-09-10 | H | L | North Hagerstown (MD) | 14 | Manchester Valley (MD) (1) | 16 | Hx 910 | |
| 2021-09-20 | H | W | North Hagerstown (MD) | 42 | Tuscarora (MD) (0) | 6 | Hx 911 | |
| 2021-09-24 | H | L | North Hagerstown (MD) | 13 | Jefferson (10) | 56 | Hx 112 | |
| 2021-10-01 | A | L | North Hagerstown (MD) | 0 | James Wood (VA) (7) | 52 | Hx 912 | |
| 2021-10-08 | A | L | North Hagerstown (MD) | 13 | Williamsport (MD) (1) | 32 | Hx 913 | |
| 2021-10-15 | A | L | North Hagerstown (MD) | 7 | Boonsboro (MD) (2) | 44 | Hx 914 | |
| 2021-10-22 | A | L | North Hagerstown (MD) | 6 | Spring Mills (3) | 31 | Hx 149 | |
| 2021-10-29 | H | L | North Hagerstown (MD) | 7 | South Hagerstown (MD) (4) | 28 | Hx 915 |