| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-20 | A | W | Symmes Valley (OH) | 42 | South Gallia (OH) (0) | 0 | Hx 815 | |
| 2021-08-27 | H | W | Symmes Valley (OH) | 28 | Reedsville Eastern (OH) (4) | 6 | Hx 783 | |
| 2021-09-03 | H | W | Symmes Valley (OH) | 33 | Chesapeake (OH) (0) | 0 | Hx 816 | |
| 2021-09-10 | A | W | Symmes Valley (OH) | 55 | Tug Valley (4) | 13 | Hx 445 | |
| 2021-09-25 | H | W | Symmes Valley (OH) | 32 | Huntington (OH) (0) | 26 | Hx 1166 | |
| 2021-09-30 | A | W | Symmes Valley (OH) | 34 | Beaver Eastern (OH) (0) | 0 | Hx 819 | |
| 2021-10-08 | H | L | Symmes Valley (OH) | 0 | Sciotoville Community (OH) (2) | 34 | Hx 820 | |
| 2021-10-15 | H | W | Symmes Valley (OH) | 34 | Portsmouth Notre Dame (OH) (0) | 28 | Hx 821 | |
| 2021-10-22 | A | W | Symmes Valley (OH) | 15 | Northwest McDermott (OH) (0) | 13 | Hx 822 |