| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-20 | H | W | Reedsville Eastern (OH) | 39 | Green (OH) (0) | 8 | Hx 782 | |
| 2021-08-27 | A | L | Reedsville Eastern (OH) | 6 | Symmes Valley (OH) (8) | 28 | Hx 783 | |
| 2021-09-03 | H | L | Reedsville Eastern (OH) | 14 | Fairfield Christian Acad. (OH) (2) | 21 | Hx 784 | |
| 2021-09-17 | H | L | Reedsville Eastern (OH) | 27 | Caldwell (OH) (4) | 29 | Hx 785 | |
| 2021-09-24 | H | L | Reedsville Eastern (OH) | 0 | Waterford (OH) (6) | 32 | Hx 786 | |
| 2021-10-08 | A | W | Reedsville Eastern (OH) | 46 | South Gallia (OH) (0) | 0 | Hx 788 | |
| 2021-10-15 | H | W | Reedsville Eastern (OH) | 46 | Belpre (OH) (1) | 0 | Hx 789 | |
| 2021-10-23 | A | W | Reedsville Eastern (OH) | 41 | Racine Southern (OH) (4) | 14 | Hx 780 |