| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | L | Craig County (VA) | 6 | Bland (VA) (1) | 8 | Hx 662 | |
| 2021-09-03 | H | W | Craig County (VA) | 26 | Auburn (VA) (0) | 7 | Hx 1014 | |
| 2021-09-24 | A | L | Craig County (VA) | 16 | Twin Valley (VA) (7) | 40 | Hx 1015 | |
| 2021-10-01 | A | W | Craig County (VA) | 34 | Roanoke Catholic (VA) (1) | 18 | Hx 1016 | |
| 2021-10-08 | H | L | Craig County (VA) | 0 | Eastern Montgomery (VA) (3) | 26 | Hx 1017 | |
| 2021-10-15 | H | L | Craig County (VA) | 0 | McCluer (VA) (3) | 40 | Hx 1018 | |
| 2021-10-26 | H | W | Craig County (VA) | 40 | Montcalm (2) | 8 | Hx 1196 | |
| 2021-10-29 | H | L | Craig County (VA) | 6 | Narrows (VA) (2) | 38 | Hx 1019 | |
| 2021-11-02 | A | L | Craig County (VA) | 10 | Bath County (VA) (1) | 19 | Hx 994 | |
| 2021-11-05 | A | L | Craig County (VA) | 14 | Covington (VA) (4) | 28 | Hx 1013 |