| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-09-03 | H | W | Twin Valley (VA) | 52 | Montcalm (2) | 6 | Hx 423 | |
| 2021-09-10 | A | W | Twin Valley (VA) | 30 | Walker (VA) (0) | 0 | Hx 1113 | |
| 2021-09-17 | A | W | Twin Valley (VA) | 16 | Northwood (VA) (0) | 9 | Hx 1111 | |
| 2021-09-24 | H | W | Twin Valley (VA) | 40 | Craig County (VA) (3) | 16 | Hx 1015 | |
| 2021-10-01 | H | L | Twin Valley (VA) | 30 | Twin Springs (VA) (5) | 50 | Hx 1112 | |
| 2021-10-08 | A | L | Twin Valley (VA) | 14 | River View (4) | 30 | Hx 438 | |
| 2021-10-22 | H | W | Twin Valley (VA) | 1 | Rye Cove (VA) (0) | 0 | Hx 1236 | |
| 2021-10-28 | A | L | Twin Valley (VA) | 26 | Grundy (VA) (4) | 52 | Hx 1036 | |
| 2021-11-03 | H | W | Twin Valley (VA) | 50 | Honaker (VA) (2) | 36 | Hx 1110 | |
| 2021-11-06 | A | W | Twin Valley (VA) | 34 | Hurley (VA) (2) | 28 | Hx 1041 |