| Date | H/A | W/L | Team | Score | Opponent | Score | |||
| 2021-03-05 | H | W | James Monroe | 63 | Mt. View | 40 | 216 | ||
| 2021-03-11 | H | W | James Monroe | 79 | Montcalm | 40 | 220 | ||
| 2021-03-13 | H | W | James Monroe | 78 | Richwood | 47 | 218 | ||
| 2021-03-15 | H | W | James Monroe | 71 | Greater Beckley Christian | 44 | 219 | ||
| 2021-03-20 | H | W | James Monroe | 73 | Meadow Bridge | 35 | 217 | ||
| 2021-03-22 | A | W | James Monroe | 69 | Greenbrier West | 64 | 160 | ||
| 2021-03-23 | H | W | James Monroe | 74 | Montcalm | 23 | 1076 | ||
| 2021-03-26 | A | W | James Monroe | 84 | River View | 49 | 865 | ||
| 2021-03-29 | H | W | James Monroe | 87 | Summers County | 49 | 221 | ||
| 2021-04-01 | A | W | James Monroe | 93 | Independence | 67 | 212 | ||
| 2021-04-02 | H | W | James Monroe | 61 | Webster County | 51 | 1088 | ||
| 2021-04-06 | H | W | James Monroe | 65 | Greenbrier West | 44 | 222 | ||
| 2021-04-08 | H | W | James Monroe | 100 | Pocahontas County | 52 | 1103 | ||
| 2021-04-09 | H | W | James Monroe | 86 | River View | 49 | 223 | ||
| 2021-04-10 | A | W | James Monroe | 110 | Richwood | 53 | 866 | ||
| 2021-04-13 | A | L | James Monroe | 55 | Greater Beckley Christian | 58 | 868 | ||
| 2021-04-22 | H | W | James Monroe | 101 | River View | 65 | 1218 | ||
| 2021-04-24 | H | W | James Monroe | 69 | Greater Beckley Christian | 52 | 1247 | ||
| 2021-04-28 | H | L | James Monroe | 57 | Greenbrier West | 64 | 1 OT | 1262 |