| Date | H/A | W/L | Team | Score | Opponent | Score | |||
| 2021-03-05 | H | L | Greenbrier West | 73 | Tug Valley | 75 | 157 | ||
| 2021-03-09 | A | W | Greenbrier West | 74 | Clay-Battelle | 58 | 70 | ||
| 2021-03-17 | N | W | Greenbrier West | 67 | Williamstown | 66 | WV State | 821 | |
| 2021-03-19 | A | L | Greenbrier West | 69 | Tug Valley | 80 | 814 | ||
| 2021-03-22 | H | L | Greenbrier West | 64 | James Monroe | 69 | 160 | ||
| 2021-03-26 | H | W | Greenbrier West | 81 | Meadow Bridge | 51 | 161 | ||
| 2021-03-27 | A | W | Greenbrier West | 75 | Summers County | 32 | 816 | ||
| 2021-03-29 | H | W | Greenbrier West | 87 | Nicholas County | 75 | 1 OT | 1079 | |
| 2021-03-31 | N | L | Greenbrier West | 46 | Webster County | 75 | Beckley Armory | 818 | |
| 2021-04-01 | N | L | Greenbrier West | 57 | Westside | 75 | Beckley Armory | 819 | |
| 2021-04-06 | A | L | Greenbrier West | 44 | James Monroe | 65 | 222 | ||
| 2021-04-08 | H | W | Greenbrier West | 86 | Summers County | 35 | 162 | ||
| 2021-04-10 | A | W | Greenbrier West | 73 | South Harrison | 63 | WVHIT D1 Championship | 1144 | |
| 2021-04-13 | H | W | Greenbrier West | 87 | Richwood | 60 | 158 | ||
| 2021-04-16 | H | W | Greenbrier West | 74 | Midland Trail | 57 | 163 | ||
| 2021-04-20 | H | W | Greenbrier West | 100 | Richwood | 46 | 1202 | ||
| 2021-04-22 | A | L | Greenbrier West | 57 | Webster County | 64 | 1219 | ||
| 2021-04-28 | A | W | Greenbrier West | 64 | James Monroe | 57 | 1 OT | 1262 | |
| 2021-05-04 | A | L | Greenbrier West | 45 | Pendleton County | 59 | 1285 |