| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-21 | H | W | Tuscarawas Cent. Cath. (OH) | 31 | Fisher Catholic (OH) (0) | 17 | Hx 835 | |
| 2021-08-27 | A | L | Tuscarawas Cent. Cath. (OH) | 25 | Edison Local (OH) (6) | 29 | Hx 1133 | |
| 2021-09-04 | H | L | Tuscarawas Cent. Cath. (OH) | 18 | Wheeling Central (9) | 52 | Hx 452 | |
| 2021-09-10 | A | L | Tuscarawas Cent. Cath. (OH) | 0 | Garaway (OH) (1) | 42 | Hx 837 | |
| 2021-09-18 | H | L | Tuscarawas Cent. Cath. (OH) | 14 | Sandy Valley (OH) (1) | 40 | Hx 838 | |
| 2021-09-24 | A | L | Tuscarawas Cent. Cath. (OH) | 14 | Buckeye Trail (OH) (1) | 44 | Hx 839 | |
| 2021-10-01 | H | W | Tuscarawas Cent. Cath. (OH) | 34 | Newcomerstown (OH) (0) | 0 | Hx 840 | |
| 2021-10-08 | A | L | Tuscarawas Cent. Cath. (OH) | 6 | East Canton (OH) (1) | 27 | Hx 841 | |
| 2021-10-15 | A | L | Tuscarawas Cent. Cath. (OH) | 13 | Malvern (OH) (2) | 40 | Hx 842 | |
| 2021-10-23 | H | W | Tuscarawas Cent. Cath. (OH) | 38 | Strasburg-Franklin (OH) (0) | 20 | Hx 843 |