| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | H | W | Edison Local (OH) | 29 | Tuscarawas Cent. Cath. (OH) (3) | 25 | Hx 1133 | |
| 2021-09-04 | A | W | Edison Local (OH) | 42 | Steubenville Central (OH) (3) | 13 | Hx 810 | |
| 2021-09-10 | H | W | Edison Local (OH) | 35 | Mathews (OH) (6) | 18 | Hx 757 | |
| 2021-09-17 | A | L | Edison Local (OH) | 21 | Beaver Local (OH) (3) | 27 | Hx 684 | |
| 2021-09-24 | H | W | Edison Local (OH) | 21 | Toronto (OH) (5) | 20 | Hx 826 | |
| 2021-10-01 | A | W | Edison Local (OH) | 34 | East Liverpool (OH) (3) | 24 | Hx 704 | |
| 2021-10-22 | H | W | Edison Local (OH) | 12 | Indian Creek (OH) (0) | 7 | Hx 728 |