| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | H | W | Meadow Bridge | 26 | Van (5) | 14 | Hx 549 | |
| 2021-09-10 | A | L | Meadow Bridge | 0 | Midland Trail (6) | 33 | Hx 551 | |
| 2021-09-17 | A | L | Meadow Bridge | 12 | James Monroe (8) | 50 | Hx 537 | |
| 2021-10-01 | H | L | Meadow Bridge | 12 | Greenbrier West (6) | 51 | Hx 516 | |
| 2021-10-08 | H | W | Meadow Bridge | 42 | Webster County (2) | 14 | Hx 552 | |
| 2021-10-15 | A | W | Meadow Bridge | 22 | Summers County (2) | 6 | Hx 553 | |
| 2021-10-19 | A | L | Meadow Bridge | 18 | Richwood (3) | 22 | Hx 550 | |
| 2021-10-22 | A | W | Meadow Bridge | 34 | Montcalm (2) | 0 | Hx 555 | |
| 2021-10-29 | H | W | Meadow Bridge | 22 | Sherman (6) | 14 | Hx 554 | |
| 2021-11-05 | H | W | Meadow Bridge | 24 | Gilmer County (7) | 14 | Hx 512 | |
| 2021-11-13 | A | L | Meadow Bridge | 6 | East Hardy (10) | 45 | 3-14 1st RD | Hx 1270 |