| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | L | Greenbrier West | 20 | Buffalo (5) | 21 | 1 OT Hx 461 | |
| 2021-09-03 | A | W | Greenbrier West | 20 | Summers County (2) | 8 | Hx 513 | |
| 2021-09-10 | H | W | Greenbrier West | 32 | Pocahontas County (5) | 0 | Hx 517 | |
| 2021-09-17 | H | W | Greenbrier West | 58 | Webster County (2) | 6 | Hx 515 | |
| 2021-10-01 | A | W | Greenbrier West | 51 | Meadow Bridge (6) | 12 | Hx 516 | |
| 2021-10-08 | H | L | Greenbrier West | 14 | James Monroe (8) | 20 | Hx 514 | |
| 2021-10-15 | A | W | Greenbrier West | 50 | Richwood (3) | 8 | Hx 518 | |
| 2021-10-22 | A | W | Greenbrier West | 38 | Sherman (6) | 8 | Hx 519 | |
| 2021-10-29 | H | L | Greenbrier West | 8 | Midland Trail (6) | 33 | Hx 520 | |
| 2021-11-05 | H | L | Greenbrier West | 14 | Mt. View (10) | 18 | Hx 521 | |
| 2021-11-13 | A | L | Greenbrier West | 20 | Williamstown (11) | 48 | 6-11 1st RD | Hx 1271 |