| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | A | L | Midland Trail | 21 | Clay County (3) | 22 | Hx 230 | |
| 2021-09-03 | H | W | Midland Trail | 34 | Tolsia (0) | 20 | Hx 556 | |
| 2021-09-10 | H | W | Midland Trail | 33 | Meadow Bridge (6) | 0 | Hx 551 | |
| 2021-10-01 | H | L | Midland Trail | 22 | Nicholas County (6) | 47 | Hx 332 | |
| 2021-10-08 | H | L | Midland Trail | 21 | Independence (8) | 60 | Hx 285 | |
| 2021-10-15 | A | L | Midland Trail | 7 | James Monroe (8) | 20 | Hx 538 | |
| 2021-10-18 | A | W | Midland Trail | 35 | Summers County (2) | 14 | Hx 1184 | |
| 2021-10-22 | A | W | Midland Trail | 41 | Richwood (3) | 2 | Hx 557 | |
| 2021-10-29 | A | W | Midland Trail | 33 | Greenbrier West (6) | 8 | Hx 520 | |
| 2021-11-05 | H | W | Midland Trail | 42 | Pocahontas County (5) | 6 | Hx 559 | |
| 2021-11-12 | A | L | Midland Trail | 21 | Doddridge County (11) | 40 | 2-15 1st RD | Hx 1268 |