| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-20 | H | W | Mathews (OH) | 6 | Steubenville Central (OH) (3) | 0 | Hx 754 | |
| 2021-09-03 | A | W | Mathews (OH) | 46 | Sebring McKinley (OH) (0) | 12 | Hx 755 | |
| 2021-09-10 | A | L | Mathews (OH) | 18 | Edison Local (OH) (6) | 35 | Hx 757 | |
| 2021-09-17 | A | L | Mathews (OH) | 6 | Madonna (6) | 14 | Hx 415 | |
| 2021-09-24 | H | W | Mathews (OH) | 38 | St. John and Paul (OH) (0) | 0 | Hx 1165 | |
| 2021-10-01 | H | W | Mathews (OH) | 38 | Fairport Harding (OH) (0) | 0 | Hx 759 | |
| 2021-10-09 | A | W | Mathews (OH) | 36 | St. John and Paul (OH) (0) | 0 | Hx 760 | |
| 2021-10-15 | H | W | Mathews (OH) | 42 | Windham (OH) (1) | 0 | Hx 761 | |
| 2021-10-22 | A | L | Mathews (OH) | 16 | Pymatoning Valley (OH) (1) | 24 | Hx 762 |