| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 2021-08-27 | H | L | Salem (VA) | 21 | Martinsburg (13) | 35 | Hx 132 | |
| 2021-09-10 | A | W | Salem (VA) | 46 | William Fleming (VA) (0) | 20 | Hx 973 | |
| 2021-09-17 | A | W | Salem (VA) | 42 | Northside (VA) (0) | 0 | Hx 974 | |
| 2021-10-01 | H | W | Salem (VA) | 24 | Christiansburg (VA) (1) | 7 | Hx 976 | |
| 2021-10-08 | A | W | Salem (VA) | 55 | Pulaski County (VA) (4) | 6 | Hx 977 | |
| 2021-10-19 | H | W | Salem (VA) | 49 | Franklin County (VA) (0) | 7 | Hx 972 | |
| 2021-10-22 | A | W | Salem (VA) | 35 | Cave Spring (VA) (0) | 0 | Hx 978 | |
| 2021-10-29 | H | W | Salem (VA) | 42 | Hidden Valley (VA) (1) | 14 | Hx 979 | |
| 2021-11-02 | A | W | Salem (VA) | 1 | Blacksburg (VA) (0) | 0 | Hx 1198 | |
| 2021-11-05 | H | W | Salem (VA) | 37 | Patrick Henry - Roanoke (VA) (1) | 13 | Hx 980 |