| Date | H/A | W/L | Team | Score | Opponent | Score | ||
| 0000-00-00 | H | Pulaski County (VA) | Christiansburg (VA) (1) | Hx 1084 | ||||
| 2021-08-27 | A | W | Pulaski County (VA) | 20 | Northside (VA) (0) | 17 | Hx 1078 | |
| 2021-09-03 | A | W | Pulaski County (VA) | 49 | Jefferson Forest (VA) (0) | 16 | Hx 1139 | |
| 2021-09-10 | H | L | Pulaski County (VA) | 33 | James Wood (VA) (7) | 34 | Hx 1156 | |
| 2021-09-24 | H | W | Pulaski County (VA) | 42 | Cave Spring (VA) (0) | 7 | Hx 1080 | |
| 2021-10-01 | A | L | Pulaski County (VA) | 20 | Hidden Valley (VA) (1) | 28 | Hx 1081 | |
| 2021-10-08 | H | L | Pulaski County (VA) | 6 | Salem (VA) (9) | 55 | Hx 977 | |
| 2021-10-15 | A | W | Pulaski County (VA) | 49 | Blacksburg (VA) (0) | 7 | Hx 1082 | |
| 2021-10-22 | H | L | Pulaski County (VA) | 18 | Graham (VA) (9) | 58 | Hx 1026 | |
| 2021-10-29 | A | L | Pulaski County (VA) | 13 | Patrick Henry - Roanoke (VA) (1) | 42 | Hx 1083 |